# Hermetica Supplement & Drug Interaction Database

**Canonical URL:** https://ingredients.hermeticasuperfoods.com/interactions
**Total Interactions:** 121,278
**Total Substances:** 493
**Data Source:** Hermetica Superfoods Ingredient Encyclopedia

## Overview

The Hermetica Interaction Database is one of the most comprehensive open-access supplement and drug interaction resources available. It covers herb-drug, herb-herb, supplement-drug, and supplement-supplement interactions, ranked by severity and evidence level.

## Interactions by Severity

| Severity | Count |
|---|---|
| CONTRAINDICATED | 63 |
| MAJOR | 284 |
| MODERATE | 257 |
| MINOR | 29 |
| SAFE | 120,645 |

## How to Use This Database

- Search by substance: `https://ingredients.hermeticasuperfoods.com/interactions/{substance-slug}`
- Check a specific pair: `https://ingredients.hermeticasuperfoods.com/interactions/{substance-a}/{substance-b}`
- API access: `https://ingredients.hermeticasuperfoods.com/api/v1/interactions`

## Severity Scale

| Level | Meaning |
|---|---|
| CONTRAINDICATED | Do not combine under any circumstances |
| MAJOR | Serious risk; medical supervision required |
| MODERATE | Monitor closely; dose adjustment may be needed |
| MINOR | Generally manageable; be aware |
| BENEFICIAL | Synergistic — combining enhances both effects |


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*Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com*
*License: CC BY-NC-SA 4.0 — Attribution required. Commercial use: admin@hermeticasuperfoods.com*