St. Johns Wort Interactions

492 known interactions for St. Johns Wort. Click any interaction for the full evidence-based breakdown.

🛑 Contraindicated (10)

St. Johns Wort + Citalopram🔴 STOP — Contraindicated. Do not take St. Johns Wort with Citalopram. This combination can cause serious harm or death.
St. Johns Wort + Desvenlafaxine🔴 STOP — Contraindicated. Do not take St. Johns Wort with Desvenlafaxine. This combination can cause serious harm or death.
St. Johns Wort + Duloxetine🔴 STOP — Contraindicated. Do not take St. Johns Wort with Duloxetine. This combination can cause serious harm or death.
St. Johns Wort + Escitalopram🔴 STOP — Contraindicated. Do not take St. Johns Wort with Escitalopram. This combination can cause serious harm or death.
St. Johns Wort + Fluoxetine🔴 STOP — Contraindicated. Do not take St. Johns Wort with Fluoxetine. This combination can cause serious harm or death.
St. Johns Wort + Fluvoxamine🔴 STOP — Contraindicated. Do not take St. Johns Wort with Fluvoxamine. This combination can cause serious harm or death.
St. Johns Wort + Paroxetine🔴 STOP — Contraindicated. Do not take St. Johns Wort with Paroxetine. This combination can cause serious harm or death.
St. Johns Wort + Sertraline🔴 STOP — Contraindicated. Do not take St. Johns Wort with Sertraline. This combination can cause serious harm or death.
St. Johns Wort + Tramadol🔴 STOP — Contraindicated. Do not take St. Johns Wort with Tramadol. This combination can cause serious harm or death.
St. Johns Wort + Venlafaxine🔴 STOP — Contraindicated. Do not take St. Johns Wort with Venlafaxine. This combination can cause serious harm or death.

⚠️ Major (13)

⚡ Moderate (1)

St. Johns Wort + Modafinil🟡 USE CAUTION — St. Johns Wort and Modafinil may interact. Talk to your doctor before combining.

✅ Safe (468)