Clarithromycin Interactions

492 known interactions for Clarithromycin. Click any interaction for the full evidence-based breakdown.

🛑 Contraindicated (6)

Clarithromycin + ColchicineFDA-documented interaction. Contraindicated in renal/hepatic impairment. In normal function, colchicine dose must be significantly reduced. Fatal cases reported.
Clarithromycin + IvabradineFDA contraindication on ivabradine label. Strong CYP3A4 inhibitors are contraindicated. Can cause severe symptomatic bradycardia.
Clarithromycin + LovastatinFDA contraindication. Same mechanism as simvastatin. Suspend lovastatin during clarithromycin or use alternative antibiotic.
Clarithromycin + LurasidoneFDA contraindication on lurasidone label. Do not co-administer with strong CYP3A4 inhibitors.
Clarithromycin + RanolazineFDA contraindication on ranolazine label. Strong CYP3A4 inhibitors contraindicated due to QT prolongation risk from elevated ranolazine levels.
Clarithromycin + SimvastatinFDA contraindication. Temporarily discontinue simvastatin during clarithromycin treatment.

⚠️ Major (8)

✅ Safe (478)