Digoxin Interactions

492 known interactions for Digoxin. Click any interaction for the full evidence-based breakdown.

⚠️ Major (9)

Digoxin + AmiodaroneFDA-documented interaction. Reduce digoxin dose by approximately 50% when starting amiodarone. Monitor digoxin levels closely.
Digoxin + ClarithromycinFDA-documented interaction. Monitor digoxin levels during and after clarithromycin treatment. Dose reduction may be needed.
Digoxin + DiltiazemFDA-documented dual interaction: pharmacokinetic (P-gp inhibition increases digoxin levels) plus pharmacodynamic (additive AV nodal depression). Monitor heart rate and digoxin levels.
Digoxin + EmodinEmodin and Digoxin — DANGEROUS: Risk of Digoxin Toxicity
Digoxin + ErythromycinFDA-documented interaction. Monitor digoxin levels. Consider alternative antibiotics.
Digoxin + FurosemideFDA-documented interaction. Electrolyte monitoring essential. Potassium supplementation usually needed. Maintain potassium >4.0 mEq/L in digoxin patients.
Digoxin + HydrochlorothiazideFDA-documented interaction. Same electrolyte-mediated mechanism as loop diuretics. Monitor and supplement potassium.
Digoxin + Licorice RootDANGEROUS — licorice root must be avoided while on digoxin
Digoxin + St. Johns WortDANGEROUS — St. Johns Wort makes digoxin less effective

⚡ Moderate (5)

✅ Safe (478)