Combined Oral Contraceptives Interactions

492 known interactions for Combined Oral Contraceptives. Click any interaction for the full evidence-based breakdown.

⚠️ Major (6)

Combined Oral Contraceptives + Activated CharcoalDANGEROUS — contraceptive failure risk
Combined Oral Contraceptives + AdrafinilAdrafinil and Hormonal Contraceptives — Major Interaction (Reduced Contraceptive Efficacy)
Combined Oral Contraceptives + CarbamazepineFDA-documented interaction. Contraceptive failure has been reported. Use additional or alternative contraception.
Combined Oral Contraceptives + PhenytoinFDA-documented interaction. Same mechanism as carbamazepine. Contraceptive failure risk is significant.
Combined Oral Contraceptives + RifampinFDA-documented interaction. Rifampin is the most potent known inducer of oral contraceptive metabolism. Backup contraception is mandatory.
Combined Oral Contraceptives + St. Johns Wort🔴 CAUTION — Major interaction between St. Johns Wort and Combined Oral Contraceptives. Avoid unless under direct medical supervision.

⚡ Moderate (2)

✅ Safe (484)