Apixaban Interactions

492 known interactions for Apixaban. Click any interaction for the full evidence-based breakdown.

⚠️ Major (8)

Apixaban + Activated CharcoalDANGEROUS — loss of anticoagulation
Apixaban + ClarithromycinFDA apixaban label recommends dose reduction when used with strong dual CYP3A4 and P-gp inhibitors. Consider alternative antibiotics.
Apixaban + Ginkgo Biloba🔴 CAUTION — Major interaction between Ginkgo Biloba and Apixaban. Avoid unless under direct medical supervision.
Apixaban + LumbrokinaseLumbrokinase + Apixaban — MAJOR Bleeding Risk (Contraindicated)
Apixaban + NattokinaseNattokinase + Apixaban — MAJOR Bleeding Risk (Contraindicated)
Apixaban + RifampinFDA-documented interaction. Apixaban levels reduced ~54%. Avoid concurrent use. Consider warfarin (monitorable) during rifampin treatment.
Apixaban + SerrapeptaseSerrapeptase + Apixaban — MAJOR Bleeding Risk
Apixaban + St. Johns Wort🔴 CAUTION — Major interaction between St. Johns Wort and Apixaban. Avoid unless under direct medical supervision.

⚡ Moderate (4)

ℹ️ Minor (1)

Apixaban + Omega-3 Fish Oil🟡 LOW RISK — Omega-3 Fish Oil and Apixaban have a minor interaction. Generally safe with awareness.

✅ Safe (479)