Clopidogrel Interactions

492 known interactions for Clopidogrel. Click any interaction for the full evidence-based breakdown.

⚠️ Major (7)

Clopidogrel + Esomeprazole🔴 AVOID — FDA safety communication: esomeprazole inhibits CYP2C19, reducing clopidogrel activation. Same mechanism as omeprazole. Use pantoprazole or H2 blockers instead.
Clopidogrel + Ginkgo Biloba🔴 CAUTION — Major interaction between Ginkgo Biloba and Clopidogrel. Avoid unless under direct medical supervision.
Clopidogrel + LumbrokinaseLumbrokinase + Clopidogrel — MAJOR Bleeding Risk (Contraindicated)
Clopidogrel + NattokinaseNattokinase + Clopidogrel — MAJOR Bleeding Risk (Contraindicated)
Clopidogrel + Omeprazole🔴 AVOID — FDA 2009 safety communication: omeprazole blocks CYP2C19 activation of clopidogrel, reducing platelet inhibition. Use pantoprazole or H2 blockers instead.
Clopidogrel + SerrapeptaseSerrapeptase + Clopidogrel — MAJOR Bleeding Risk
Clopidogrel + WarfarinFDA-documented interaction. Sometimes prescribed together intentionally (mechanical valve + stent) but bleeding risk is very high. Triple therapy (warfarin + clopidogrel + aspirin) is extremely high risk.

⚡ Moderate (3)

ℹ️ Minor (1)

Clopidogrel + Omega-3 Fish Oil🟡 LOW RISK — Omega-3 Fish Oil and Clopidogrel have a minor interaction. Generally safe with awareness.

✅ Safe (481)