Paroxetine Interactions

492 known interactions for Paroxetine. Click any interaction for the full evidence-based breakdown.

🛑 Contraindicated (2)

Paroxetine + LinezolidFDA contraindication — do not co-administer. Use alternative antibiotics or discontinue paroxetine before starting linezolid.
Paroxetine + St. Johns Wort🔴 STOP — Contraindicated. Do not take St. Johns Wort with Paroxetine. This combination can cause serious harm or death.

⚠️ Major (11)

Paroxetine + 5-HTP🔴 CAUTION — Major interaction between 5-HTP and Paroxetine. Avoid unless under direct medical supervision.
Paroxetine + AmitriptylineDANGEROUS — potent CYP2D6 inhibition elevates TCA levels
Paroxetine + AripiprazoleFDA aripiprazole label — reduce dose 50% with strong CYP2D6 inhibitors.
Paroxetine + AtomoxetineFDA-documented. Paroxetine is worst CYP2D6 inhibitor for this interaction. Start atomoxetine at low dose.
Paroxetine + Cyclobenzaprine🔴 CAUTION — Major interaction between Paroxetine and Cyclobenzaprine. Avoid unless under direct medical supervision.
Paroxetine + DextromethorphanDANGEROUS — Paroxetine is especially risky due to strong CYP2D6 inhibition
Paroxetine + FlecainideFDA-documented interaction. Paroxetine is the most potent CYP2D6 inhibitor among SSRIs. Use alternative SSRI.
Paroxetine + MetoprololFDA-documented CYP2D6 interaction. Paroxetine is the strongest CYP2D6 inhibitor among SSRIs. Use alternative beta-blocker or alternative SSRI.
Paroxetine + TamoxifenFDA-documented interaction. Paroxetine is the strongest CYP2D6 inhibitor among SSRIs. Clinical studies suggest increased breast cancer recurrence risk. Avoid this combination.
Paroxetine + TianeptineTianeptine and SSRIs/SNRIs — Major Interaction (Serotonin Syndrome Risk)
Paroxetine + Tramadol🔴 CAUTION — Major interaction between Paroxetine and Tramadol. Avoid unless under direct medical supervision.

⚡ Moderate (4)

✅ Safe (475)