Carbamazepine Interactions

492 known interactions for Carbamazepine. Click any interaction for the full evidence-based breakdown.

⚠️ Major (7)

Carbamazepine + ClarithromycinFDA-documented interaction. Carbamazepine levels can double. Acute toxicity risk. Use alternative antibiotics or monitor carbamazepine levels very closely.
Carbamazepine + Combined Oral ContraceptivesFDA-documented interaction. Contraceptive failure has been reported. Use additional or alternative contraception.
Carbamazepine + LamotrigineFDA lamotrigine label provides specific dosing schedules for patients on enzyme inducers. Lamotrigine maintenance dose with carbamazepine is roughly double the dose without it.
Carbamazepine + St. Johns WortDANGEROUS — unpredictable additive enzyme induction
Carbamazepine + Valproic AcidFDA-documented bidirectional interaction. Requires monitoring of both drug levels. Carbamazepine epoxide levels should be monitored (not measured on standard carbamazepine levels).
Carbamazepine + WarfarinFDA-documented interaction. Warfarin dose increase usually needed. INR monitoring essential when starting, stopping, or adjusting carbamazepine dose.
Carbamazepine + WormwoodWormwood and Anticonvulsants — CONTRAINDICATED (Seizure Threshold Lowering)

⚡ Moderate (7)

✅ Safe (478)