Licorice Root Interactions

492 known interactions for Licorice Root. Click any interaction for the full evidence-based breakdown.

⚠️ Major (4)

Licorice Root + DigoxinDANGEROUS — licorice root must be avoided while on digoxin
Licorice Root + Furosemide🔴 AVOID — Both furosemide and licorice root cause significant potassium loss. Combined use creates dangerous hypokalemia risk that can trigger cardiac arrhythmias.
Licorice Root + Hydrochlorothiazide🔴 AVOID — Both hydrochlorothiazide and licorice root deplete potassium. Combined use creates dangerous hypokalemia risk that can trigger cardiac arrhythmias.
Licorice Root + Spironolactone🔴 AVOID — Licorice root directly opposes spironolactone pharmacologically. Glycyrrhizin activates mineralocorticoid receptors while spironolactone blocks them, rendering the medication ineffective.

⚡ Moderate (17)

✅ Safe (471)