Fluvoxamine Interactions

492 known interactions for Fluvoxamine. Click any interaction for the full evidence-based breakdown.

🛑 Contraindicated (1)

Fluvoxamine + St. Johns Wort🔴 STOP — Contraindicated. Do not take St. Johns Wort with Fluvoxamine. This combination can cause serious harm or death.

⚠️ Major (5)

Fluvoxamine + Caffeine🔴 MAJOR — Fluvoxamine increases Caffeine levels 5-fold. Drastically reduce caffeine.
Fluvoxamine + ClozapineFDA-documented interaction. Fluvoxamine is the strongest CYP1A2 inhibitor. Clozapine dose must be dramatically reduced (often by 2/3 to 3/4). Some clinicians intentionally use this interaction to boost clozapine levels, but only with very careful monitoring.
Fluvoxamine + DextromethorphanDANGEROUS — Fluvoxamine causes extreme DXM level elevation
Fluvoxamine + Melatonin🟡 USE CAUTION — Melatonin and Fluvoxamine may interact. Talk to your doctor before combining.
Fluvoxamine + WarfarinFDA-documented interaction. Fluvoxamine is the SSRI most likely to increase warfarin levels (strong CYP1A2 + moderate CYP2C9 inhibition). INR monitoring essential.

⚡ Moderate (2)

✅ Safe (484)