Oxycodone Interactions

492 known interactions for Oxycodone. Click any interaction for the full evidence-based breakdown.

🛑 Contraindicated (7)

Oxycodone + Alcohol⛔ CONTRAINDICATED — NEVER combine alcohol with Oxycodone.
Oxycodone + AlprazolamFDA Black Box Warning — avoid concurrent use. Deaths have occurred. If co-prescribing is unavoidable, use lowest doses and shortest duration.
Oxycodone + ClonazepamFDA Black Box Warning — avoid concurrent use unless no alternatives exist.
Oxycodone + DiazepamFDA Black Box Warning — avoid concurrent use. Use lowest doses and shortest duration if absolutely necessary.
Oxycodone + Kratom🔴 STOP — Contraindicated. Do not take Kratom with Oxycodone. This combination can cause serious harm or death.
Oxycodone + LorazepamFDA Black Box Warning — avoid concurrent prescribing. If no alternative exists, use minimum effective doses.
Oxycodone + MethadoneCONTRAINDICATED — dual full opioid agonists

⚠️ Major (10)

⚡ Moderate (2)

✅ Safe (473)