Amiodarone Interactions

492 known interactions for Amiodarone. Click any interaction for the full evidence-based breakdown.

🛑 Contraindicated (1)

Amiodarone + ZiprasidoneFDA contraindication — ziprasidone label specifically contraindicates use with drugs that prolong QT interval.

⚠️ Major (6)

Amiodarone + DigoxinFDA-documented interaction. Reduce digoxin dose by approximately 50% when starting amiodarone. Monitor digoxin levels closely.
Amiodarone + LevofloxacinBoth drugs independently prolong QT. FDA fluoroquinolone label carries Black Box Warning mentioning QT prolongation. Avoid combination if possible.
Amiodarone + MoxifloxacinFDA-documented QT risk. Moxifloxacin has the highest QT prolongation potential among fluoroquinolones. Avoid this combination.
Amiodarone + OndansetronBoth drugs prolong QT. Avoid combination if possible. If used together, ECG monitoring is essential.
Amiodarone + SimvastatinFDA simvastatin label mandates maximum dose of 20mg/day with amiodarone. Higher doses increase rhabdomyolysis risk.
Amiodarone + WarfarinFDA-documented major interaction. Warfarin dose should be reduced by 33-50% when amiodarone is started. Effect persists months after amiodarone discontinuation due to 40-55 day half-life.

✅ Safe (485)