Lithium Interactions

492 known interactions for Lithium. Click any interaction for the full evidence-based breakdown.

⚠️ Major (5)

Lithium + EnalaprilFDA-documented interaction. Monitor lithium levels when starting or adjusting enalapril.
Lithium + HydrochlorothiazideFDA-documented interaction. Thiazide diuretics are specifically called out on lithium label. Lithium dose reduction of 25-50% may be needed. Loop diuretics may be less problematic.
Lithium + IbuprofenFDA-documented interaction. Lithium levels can increase 15-53%. Monitor lithium levels when starting, stopping, or changing NSAID dose. Consider acetaminophen instead.
Lithium + LisinoprilFDA-documented interaction. ACE inhibitors can significantly raise lithium levels. Monitor lithium levels closely when starting, adjusting, or stopping ACE inhibitors.
Lithium + NaproxenFDA-documented interaction. Same mechanism as other NSAIDs. Naproxen longer half-life may cause more sustained lithium elevation.

✅ Safe (487)