Sumatriptan Interactions

492 known interactions for Sumatriptan. Click any interaction for the full evidence-based breakdown.

⚠️ Major (5)

Sumatriptan + 5-HTP🔴 CAUTION — Major interaction between 5-HTP and Sumatriptan. Avoid unless under direct medical supervision.
Sumatriptan + FluoxetineFDA warning. Same class-wide triptan-SSRI interaction. Monitor for serotonin syndrome symptoms.
Sumatriptan + Sertraline🔴 AVOID — FDA 2006 safety communication: triptan + SSRI combinations risk serotonin syndrome. Clinical significance debated but FDA warning stands. Watch for agitation, confusion, rapid heartbeat.
Sumatriptan + St. Johns Wort🔴 CAUTION — Major interaction between St. Johns Wort and Sumatriptan. Avoid unless under direct medical supervision.
Sumatriptan + VenlafaxineFDA warning applies to SNRIs as well as SSRIs. Same monitoring recommendations.

⚡ Moderate (1)

Sumatriptan + Escitalopram🟡 USE CAUTION — Escitalopram and Sumatriptan may interact. Talk to your doctor before combining.

✅ Safe (486)