Gabapentin Interactions

492 known interactions for Gabapentin. Click any interaction for the full evidence-based breakdown.

⚠️ Major (3)

Gabapentin + Hydrocodone🔴 AVOID — FDA 2019 safety communication: gabapentinoid-opioid combinations risk serious respiratory depression. Use lowest effective doses under close medical supervision.
Gabapentin + Oxycodone🔴 AVOID — FDA 2019 safety communication: gabapentinoids with opioids risk serious respiratory depression. Use lowest effective doses of both under close medical supervision.
Gabapentin + PhenibutPhenibut and Gabapentinoids — CONTRAINDICATED (Additive CNS Depression)

⚡ Moderate (1)

Gabapentin + Bacopa Monnieri🟡 CAUTION — Bacopa Monnieri has GABAergic activity that adds to Gabapentin's sedative effects. Start with lower Bacopa doses, avoid driving until you know how this combination affects you, and do not add alcohol.

ℹ️ Minor (1)

Gabapentin + Magnesium🟡 LOW RISK — Magnesium and Gabapentin have a minor interaction. Generally safe with awareness.

✅ Safe (487)