Fluconazole Interactions

492 known interactions for Fluconazole. Click any interaction for the full evidence-based breakdown.

⚠️ Major (7)

Fluconazole + ColchicineFDA-documented interaction. Colchicine dose reduction required. Contraindicated in patients with renal or hepatic impairment.
Fluconazole + Kava🔴 CAUTION — Major interaction between Kava and Fluconazole. Avoid unless under direct medical supervision.
Fluconazole + Lovastatin🔴 CAUTION — Major interaction between Lovastatin and Fluconazole. Avoid unless under direct medical supervision.
Fluconazole + PhenytoinFDA-documented interaction. Monitor phenytoin levels closely. Dose reduction may be needed. Consider alternative antifungals.
Fluconazole + SimvastatinFDA-documented interaction. Consider temporary statin discontinuation or dose reduction during fluconazole treatment.
Fluconazole + TacrolimusFDA-documented interaction. Tacrolimus dose reduction typically needed. Frequent tacrolimus level and renal function monitoring required.
Fluconazole + WarfarinFDA-documented major interaction. INR can increase 2-3 fold. Warfarin dose reduction of 25-50% typically needed. Frequent INR monitoring required.

⚡ Moderate (1)

Fluconazole + Atorvastatin🟡 USE CAUTION — Atorvastatin and Fluconazole may interact. Talk to your doctor before combining.

✅ Safe (484)