Tramadol Interactions

492 known interactions for Tramadol. Click any interaction for the full evidence-based breakdown.

🛑 Contraindicated (7)

Tramadol + Alcohol⛔ CONTRAINDICATED — NEVER combine alcohol with Tramadol. Seizure and respiratory depression risk.
Tramadol + AlprazolamFDA Black Box Warning — tramadol label specifically warns against concurrent benzodiazepine use.
Tramadol + ClonazepamFDA Black Box Warning — avoid concurrent use. Tramadol seizure risk is additive concern.
Tramadol + DiazepamFDA Black Box Warning — same risk level as other opioid-benzodiazepine combinations.
Tramadol + Kratom🔴 STOP — Contraindicated. Do not take Kratom with Tramadol. This combination can cause serious harm or death.
Tramadol + LorazepamFDA Black Box Warning applies to tramadol-benzodiazepine combinations just as it does to stronger opioids.
Tramadol + St. Johns Wort🔴 STOP — Contraindicated. Do not take St. Johns Wort with Tramadol. This combination can cause serious harm or death.

⚠️ Major (16)

✅ Safe (469)