Rasagiline Interactions

492 known interactions for Rasagiline. Click any interaction for the full evidence-based breakdown.

🛑 Contraindicated (6)

Rasagiline + Amphetamine/DextroamphetamineFDA contraindication. Risk of hypertensive crisis, hyperthermia, seizures. Do not co-administer.
Rasagiline + DuloxetineFDA contraindication on rasagiline label. 14-day washout required after stopping rasagiline before starting SNRI (or vice versa).
Rasagiline + FluoxetineFDA contraindication. 5-week washout period required after stopping fluoxetine before starting rasagiline, due to fluoxetine long half-life.
Rasagiline + LisdexamfetamineFDA contraindication. Same risk as other amphetamine + MAO inhibitor combinations.
Rasagiline + SertralineFDA contraindication on rasagiline label. At least 14 days washout required between rasagiline and SSRI (5 weeks for fluoxetine).
Rasagiline + VenlafaxineFDA contraindication. 14-day washout after stopping rasagiline. Also allow adequate venlafaxine washout before starting rasagiline.

⚠️ Major (1)

Rasagiline + MethylphenidateFDA labels warn about MAO inhibitor + stimulant combinations. Risk of hypertensive crisis.

✅ Safe (485)