Ciprofloxacin Interactions

492 known interactions for Ciprofloxacin. Click any interaction for the full evidence-based breakdown.

⚠️ Major (7)

Ciprofloxacin + Calcium🔴 CAUTION — Major interaction between Calcium and Ciprofloxacin. Avoid unless under direct medical supervision.
Ciprofloxacin + ClozapineFDA-documented interaction. Clozapine dose reduction of approximately 50% typically needed when strong CYP1A2 inhibitor is added. Monitor clozapine levels.
Ciprofloxacin + Iron🔴 CAUTION — Major interaction between Iron and Ciprofloxacin. Avoid unless under direct medical supervision.
Ciprofloxacin + Magnesium🔴 CAUTION — Major interaction between Magnesium and Ciprofloxacin. Avoid unless under direct medical supervision.
Ciprofloxacin + OlanzapineFDA-documented CYP1A2 interaction. Monitor for increased olanzapine effects. Consider dose reduction or alternative antibiotic.
Ciprofloxacin + WarfarinFDA-documented interaction. INR monitoring recommended when starting or stopping ciprofloxacin in warfarin patients.
Ciprofloxacin + Zinc🔴 CAUTION — Major interaction between Zinc and Ciprofloxacin. Avoid unless under direct medical supervision.

⚡ Moderate (3)

ℹ️ Minor (1)

Ciprofloxacin + Probiotics🟡 LOW RISK — Probiotics and Ciprofloxacin have a minor interaction. Generally safe with awareness.

✅ Safe (481)