Rivaroxaban Interactions

492 known interactions for Rivaroxaban. Click any interaction for the full evidence-based breakdown.

⚠️ Major (7)

Rivaroxaban + ClarithromycinFDA-documented interaction. Avoid strong dual CYP3A4/P-gp inhibitors with rivaroxaban. Use alternative antibiotics when possible.
Rivaroxaban + Ginkgo Biloba🔴 CAUTION — Major interaction between Ginkgo Biloba and Rivaroxaban. Avoid unless under direct medical supervision.
Rivaroxaban + LumbrokinaseLumbrokinase + Rivaroxaban — MAJOR Bleeding Risk (Contraindicated)
Rivaroxaban + NattokinaseNattokinase + Rivaroxaban — MAJOR Bleeding Risk (Contraindicated)
Rivaroxaban + RifampinFDA rivaroxaban label warns against concurrent use with strong CYP3A4 and P-gp inducers. Consider alternative anticoagulation.
Rivaroxaban + SerrapeptaseSerrapeptase + Rivaroxaban — MAJOR Bleeding Risk
Rivaroxaban + St. Johns Wort🔴 CAUTION — Major interaction between St. Johns Wort and Rivaroxaban. Avoid unless under direct medical supervision.

⚡ Moderate (3)

✅ Safe (482)