Doxycycline Interactions

492 known interactions for Doxycycline. Click any interaction for the full evidence-based breakdown.

⚠️ Major (4)

Doxycycline + Calcium🔴 CAUTION — Major interaction between Calcium and Doxycycline. Avoid unless under direct medical supervision.
Doxycycline + Iron🔴 CAUTION — Major interaction between Iron and Doxycycline. Avoid unless under direct medical supervision.
Doxycycline + Magnesium🔴 CAUTION — Major interaction between Magnesium and Doxycycline. Avoid unless under direct medical supervision.
Doxycycline + Zinc🔴 CAUTION — Major interaction between Zinc and Doxycycline. Avoid unless under direct medical supervision.

⚡ Moderate (1)

Doxycycline + Dairy🟡 CAUTION — Calcium in dairy chelates doxycycline, reducing absorption by 20-50%. Take doxycycline at least 2 hours before or after dairy products.

ℹ️ Minor (1)

Doxycycline + Probiotics🟡 LOW RISK — Probiotics and Doxycycline have a minor interaction. Generally safe with awareness.

✅ Safe (486)