Tianeptine Interactions

492 known interactions for Tianeptine. Click any interaction for the full evidence-based breakdown.

⚠️ Major (14)

Tianeptine + AlcoholTianeptine and Alcohol — CONTRAINDICATED (Additive CNS/Respiratory Depression)
Tianeptine + CitalopramTianeptine and SSRIs/SNRIs — Major Interaction (Serotonin Syndrome Risk)
Tianeptine + DesvenlafaxineTianeptine and SSRIs/SNRIs — Major Interaction (Serotonin Syndrome Risk)
Tianeptine + DuloxetineTianeptine and SSRIs/SNRIs — Major Interaction (Serotonin Syndrome Risk)
Tianeptine + EscitalopramTianeptine and SSRIs/SNRIs — Major Interaction (Serotonin Syndrome Risk)
Tianeptine + FluoxetineTianeptine and SSRIs/SNRIs — Major Interaction (Serotonin Syndrome Risk)
Tianeptine + HydrocodoneTianeptine and Opioids — CONTRAINDICATED (Additive Opioid Respiratory Depression)
Tianeptine + KratomTianeptine and Kratom — CONTRAINDICATED (Additive Opioid Toxicity)
Tianeptine + OxycodoneTianeptine and Opioids — CONTRAINDICATED (Additive Opioid Respiratory Depression)
Tianeptine + ParoxetineTianeptine and SSRIs/SNRIs — Major Interaction (Serotonin Syndrome Risk)
Tianeptine + SelegilineTianeptine and MAOIs — ABSOLUTELY CONTRAINDICATED (Serotonin Syndrome/Hypertensive Crisis)
Tianeptine + SertralineTianeptine and SSRIs/SNRIs — Major Interaction (Serotonin Syndrome Risk)
Tianeptine + TramadolTianeptine and Opioids — CONTRAINDICATED (Additive Opioid Respiratory Depression)
Tianeptine + VenlafaxineTianeptine and SSRIs/SNRIs — Major Interaction (Serotonin Syndrome Risk)

✅ Safe (478)