Fluoxetine Interactions

492 known interactions for Fluoxetine. Click any interaction for the full evidence-based breakdown.

🛑 Contraindicated (4)

Fluoxetine + LinezolidFDA contraindication. If linezolid is essential, fluoxetine must be stopped 5+ weeks beforehand due to very long half-life of active metabolite.
Fluoxetine + RasagilineFDA contraindication. 5-week washout period required after stopping fluoxetine before starting rasagiline, due to fluoxetine long half-life.
Fluoxetine + SelegilineFDA contraindication with 5-week washout requirement after fluoxetine discontinuation.
Fluoxetine + St. Johns Wort🔴 STOP — Contraindicated. Do not take St. Johns Wort with Fluoxetine. This combination can cause serious harm or death.

⚠️ Major (17)

⚡ Moderate (7)

ℹ️ Minor (1)

Fluoxetine + Melatonin🟡 LOW RISK — Melatonin and Fluoxetine have a minor interaction. Generally safe with awareness.

✅ Safe (463)