Rifampin Interactions

492 known interactions for Rifampin. Click any interaction for the full evidence-based breakdown.

🛑 Contraindicated (1)

Rifampin + LurasidoneFDA contraindication. Rifampin can reduce lurasidone exposure by approximately 80%. Lurasidone will be ineffective.

⚠️ Major (19)

Rifampin + AlprazolamDANGEROUS — benzodiazepine levels dramatically reduced
Rifampin + AmlodipineFDA-documented CYP3A4 interaction. Amlodipine efficacy reduced. May need alternative antihypertensive or higher doses with monitoring.
Rifampin + ApixabanFDA-documented interaction. Apixaban levels reduced ~54%. Avoid concurrent use. Consider warfarin (monitorable) during rifampin treatment.
Rifampin + AtorvastatinDANGEROUS — statin therapy becomes ineffective
Rifampin + ClonazepamDANGEROUS — reduced seizure/anxiety control
Rifampin + Combined Oral ContraceptivesFDA-documented interaction. Rifampin is the most potent known inducer of oral contraceptive metabolism. Backup contraception is mandatory.
Rifampin + DiazepamDANGEROUS — diazepam levels significantly reduced
Rifampin + DiltiazemFDA-documented interaction. Diltiazem may become completely ineffective. Alternative antihypertensive needed during rifampin treatment.
Rifampin + LorazepamCAUTION — lorazepam is less affected than other benzos but still impacted by rifampin UGT induction
Rifampin + LovastatinDANGEROUS — statin therapy becomes ineffective
Rifampin + MethadoneFDA-documented interaction. Can precipitate opioid withdrawal. Methadone dose increases typically needed. Very careful monitoring required when starting and stopping rifampin.
Rifampin + OxycodoneFDA-documented interaction. Oxycodone levels can decrease 50-85%. Pain management may fail. Dose escalation may be needed but increases risk when rifampin is stopped.
Rifampin + PravastatinCAUTION — pravastatin may be the best statin choice during rifampin but still monitor
Rifampin + QuetiapineFDA quetiapine label — dose increase up to 5-fold may be needed with strong CYP3A4 inducers. When rifampin stops, dose must be reduced back.
Rifampin + RivaroxabanFDA rivaroxaban label warns against concurrent use with strong CYP3A4 and P-gp inducers. Consider alternative anticoagulation.
Rifampin + RosuvastatinCAUTION — rosuvastatin is a better choice than atorvastatin/simvastatin during rifampin therapy but still affected
Rifampin + SimvastatinFDA-documented interaction. Chronic rifampin reduces simvastatin exposure by up to 87%. Statin therapy may be ineffective during rifampin treatment.
Rifampin + TacrolimusFDA-documented interaction. Rifampin can reduce tacrolimus levels by 50-80%. Massive dose increases may be needed. Organ rejection risk is high.
Rifampin + WarfarinFDA-documented major interaction. Rifampin can reduce warfarin effectiveness by 50% or more. Warfarin dose increases of 2-5x may be needed. When rifampin is stopped, warfarin levels will rise dangerously.

⚡ Moderate (5)

✅ Safe (467)