Escitalopram Interactions

492 known interactions for Escitalopram. Click any interaction for the full evidence-based breakdown.

🛑 Contraindicated (1)

Escitalopram + St. Johns Wort🔴 STOP — Contraindicated. Do not take St. Johns Wort with Escitalopram. This combination can cause serious harm or death.

⚠️ Major (7)

Escitalopram + 5-HTP🔴 CAUTION — Major interaction between 5-HTP and Escitalopram. Avoid unless under direct medical supervision.
Escitalopram + Activated CharcoalDANGEROUS — separate doses by at least 2-4 hours
Escitalopram + DextromethorphanDANGEROUS — avoid DXM with SSRIs
Escitalopram + Kratom🔴 CAUTION — Major interaction between Kratom and Escitalopram. Avoid unless under direct medical supervision.
Escitalopram + SAMeDANGEROUS — do not combine without medical supervision
Escitalopram + TianeptineTianeptine and SSRIs/SNRIs — Major Interaction (Serotonin Syndrome Risk)
Escitalopram + TramadolFDA labels warn of serotonin syndrome risk. Use alternative analgesics when possible.

⚡ Moderate (7)

✅ Safe (477)