5-HTP Interactions

492 known interactions for 5-HTP. Click any interaction for the full evidence-based breakdown.

⚠️ Major (12)

5-HTP + AmitriptylineDANGEROUS — do not combine serotonin precursors with serotonergic drugs
5-HTP + Citalopram🔴 CAUTION — Major interaction between 5-HTP and Citalopram. Avoid unless under direct medical supervision.
5-HTP + Duloxetine🔴 CAUTION — Major interaction between 5-HTP and Duloxetine. Avoid unless under direct medical supervision.
5-HTP + Escitalopram🔴 CAUTION — Major interaction between 5-HTP and Escitalopram. Avoid unless under direct medical supervision.
5-HTP + Fluoxetine🔴 CAUTION — Major interaction between 5-HTP and Fluoxetine. Avoid unless under direct medical supervision.
5-HTP + NortriptylineDANGEROUS — avoid combining
5-HTP + Paroxetine🔴 CAUTION — Major interaction between 5-HTP and Paroxetine. Avoid unless under direct medical supervision.
5-HTP + Sertraline🔴 CAUTION — Major interaction between 5-HTP and Sertraline. Avoid unless under direct medical supervision.
5-HTP + Sumatriptan🔴 CAUTION — Major interaction between 5-HTP and Sumatriptan. Avoid unless under direct medical supervision.
5-HTP + Tramadol🔴 CAUTION — Major interaction between 5-HTP and Tramadol. Avoid unless under direct medical supervision.
5-HTP + Trazodone🔴 CAUTION — Major interaction between 5-HTP and Trazodone. Avoid unless under direct medical supervision.
5-HTP + Venlafaxine🔴 CAUTION — Major interaction between 5-HTP and Venlafaxine. Avoid unless under direct medical supervision.

✅ Safe (480)