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Weight Management & Metabolism: 12 Provisional Discovery Profiles

An automated discovery list of publication-gated profiles associated with weight management. Ordering uses condition-match signals and public score. The list is provisional, has not completed accountable human review, and is not a treatment or purchase recommendation.

Data baseline audited: 2026-07-11 · Ranking method: provisional public score + condition-match signals · Pattern set: Amazonian Guaraná, Amazonian Guava, Arctic Seaberry and 9 more

The Short Answer

This automated discovery list currently places Amazonian Guaraná, Amazonian Guava, Arctic Seaberry first for weight management. Ordering uses condition-match signals, provisional public score, screened PMID depth, and recognized ingredient data. It does not identify the “best” supplements or establish efficacy, safety, or suitability; inspect each profile's review state and supported fields.

Weight Management & Metabolism ingredient profiles: provisional comparison

Use this table to compare public ranking signals, then open each profile to inspect its review state, supported fields, safety context, and screened citation mappings.

RankSupplementMatched termsPublic score stateScreened PMIDs
#1Amazonian Guaranáweight, metabol, thermogenValidated score 10/1010
#2Amazonian Guavaweight, metabolValidated score 10/101
#3Arctic SeaberrymetabolValidated score 10/101
#4Avocado Seed Flourweight, satietyValidated score 10/101
#5AdenosinemetabolValidated score 9/103
#6Alaria Esculenta ExtractmetabolValidated score 9/101
#7Anchovy OilmetabolValidated score 8.5/108
#8Ardraka (Zingiber officinale)metabolValidated score 8.5/100
  1. 1
    Amazonian Guaraná
    Seed · 10 screened PMID mappings · matches: weight, metabol, thermogen, fat burn

    Validated profile summary: Amazonian guaraná (Paullinia cupana) delivers sustained cognitive and metabolic benefits primarily through its methylxanthines—caffeine (guaranine), theobromine, and theophylline—w…

    Validated score 10/10
  2. 2
    Amazonian Guava
    Fruit · 1 screened PMID mapping · matches: weight, metabol

    Validated profile summary: Amazonian Guava (Psidium guajava), whose Amazonian origin was definitively confirmed through genomic dispersal modeling across wild populations (Arévalo-Marín et al., 2024; PMID: 3…

    Validated score 10/10
  3. 3
    Arctic Seaberry
    Berry · 1 screened PMID mapping · matches: metabol

    Validated profile summary: Arctic Seaberry (Hippophae rhamnoides) contains exceptionally high concentrations of isorhamnetin, quercetin, omega-7 fatty acids, and vitamin C that modulate PI3K/AKT/mTOR and Nrf…

    Validated score 10/10
  4. 4
    Avocado Seed Flour
    Seed · 1 screened PMID mapping · matches: weight, satiety

    Validated profile summary: Avocado Seed Flour is a powdered ingredient derived from Persea americana seeds containing high concentrations of phenolic compounds (30.80 GAE/100g), flavonoids, and condensed tan…

    Validated score 10/10
  5. 5
    Adenosine
    Compound · 3 screened PMID mappings · matches: metabol

    Validated profile summary: Adenosine is a naturally occurring nucleoside that binds to adenosine receptors (A1, A2A, A2B, A3) throughout the body. It primarily regulates cardiovascular function, sleep-wake c…

    Validated score 9/10
  6. 6
    Alaria Esculenta Extract
    Extract · 1 screened PMID mapping · matches: metabol

    Validated profile summary: Alaria esculenta extract is a North Atlantic brown macroalga rich in phlorotannins, fucoxanthin, and natural iodine that supports thyroid function and metabolic regulation. The ext…

    Validated score 9/10
  7. 7
    Anchovy Oil
    Marine-Derived · 8 screened PMID mappings · matches: metabol

    Validated profile summary: Anchovy oil is a concentrated marine lipid extract rich in EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), long-chain omega-3 fatty acids that support cardiovascular an…

    Validated score 8.5/10
  8. 8
    Ardraka (Zingiber officinale)
    Ayurveda · matches: metabol

    Validated profile summary: Ardraka (Zingiber officinale) is ginger root containing gingerols and shogaols that inhibit cyclooxygenase and lipoxygenase pathways. Clinical trials demonstrate significant reduct…

    Validated score 8.5/10
  9. 9
    ALA (Alpha-Linolenic Acid)
    Other · 3 screened PMID mappings · matches: weight, metabol

    Validated profile summary: Alpha-linolenic acid (ALA) is an essential omega-3 fatty acid that serves as a precursor to EPA and DHA, supporting cardiovascular health through anti-inflammatory pathways. It act…

    Validated score 8/10
  10. 10
    Allulose (D-Psicose)
    Other · 3 screened PMID mappings · matches: weight, metabol

    Validated profile summary: Allulose is a rare sugar that provides sweetness without calories while maintaining stable blood glucose levels. This monosaccharide bypasses normal glucose metabolism pathways, of…

    Validated score 8/10
  11. 11
    Alpha-Lipoic Acid (R-ALA)
    Other · 3 screened PMID mappings · matches: metabol

    Validated profile summary: Alpha-lipoic acid is a unique antioxidant compound that functions in both water and fat-soluble environments throughout the body. R-ALA, the naturally occurring form, enhances insu…

    Validated score 8/10
  12. 12
    5-Hydroxytryptophan (5-HTP)
    Compound · 3 screened PMID mappings · matches: weight, appetite, satiety

    Validated profile summary: 5-Hydroxytryptophan (5-HTP) is an amino acid derivative that directly converts to serotonin in the brain, bypassing the rate-limiting enzyme tryptophan hydroxylase. This mechanism …

    Validated score 7.5/10

How this provisional order is generated

This is a transparent discovery list. Rankings are generated from the Hermetica ingredient graph, provisional public scores, screened PMID mappings, and condition-pattern matching. Rank does not prove efficacy, safety, or human review.

MethodologyReview the evidence systemEditorial teamReview the evidence systemLab-test standardsReview the evidence systemLatest researchReview the evidence system

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Frequently asked

What does this weight management profile list show?
It shows publication-gated profiles associated with weight management by automated condition-match and public-score signals: Amazonian Guaraná, Amazonian Guava, Arctic Seaberry, Avocado Seed Flour, Adenosine, Alaria Esculenta Extract, Anchovy Oil, Ardraka (Zingiber officinale), ALA (Alpha-Linolenic Acid), Allulose (D-Psicose), Alpha-Lipoic Acid (R-ALA), 5-Hydroxytryptophan (5-HTP). It is a discovery index, not a clinical ranking. Review state and supported fields vary by profile.
Does the first profile have the strongest clinical evidence for weight management?
No. Amazonian Guaraná appears first by condition-match signals and provisional public score, with 10 screened PMID mappings. That order does not establish clinical efficacy, comparative superiority, or validated evidence.
How were these ingredients ranked?
Each public profile is ranked by condition-pattern matching, normalized public score, entity recognition, and presentation signals. Validation status is separate from stack order.

Other condition stacks

These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.