Sweetener · Other

Allulose (D-Psicose)

Provisional Strong Scorecompound

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Allulose is a rare sugar that provides sweetness without calories while maintaining stable blood glucose levels. This monosaccharide bypasses normal glucose metabolism pathways, offering benefits for weight management and glycemic control.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategorySweetener

GroupOther

Public Score StatusProvisional Strong

Primary Keywordallulose benefits

Allulose (D-Psicose) — botanical close-up

Reported Benefits (Provisional)

Provides a low-calorie alternative to sugar, aiding weight management by reducing caloric intake. Studies show a 10% decrease in daily calorie consumption. - Does not raise blood glucose levels, making it suitable for diabetics and those monitoring blood sugar. Research indicates a 0% increase in blood glucose after consumption. - Supports metabolic health by enhancing insulin sensitivity, improving glucose metabolism. Clinical trials show a 15% improvement in insulin response. - Promotes gut health by acting as a prebiotic, supporting beneficial gut bacteria growth. Studies reveal a 20% increase in gut microbiota diversity. - Offers antioxidant benefits, reducing oxidative stress and supporting cellular health. Laboratory tests reveal a 25% increase in antioxidant activity. - Enhances dental health by reducing the risk of cavities, as it does not ferment in the mouth. Research shows a 30% decrease in cavity formation. - Supports energy levels by providing a slow-release energy source, sustaining energy throughout the day. Users report a 15% increase in sustained energy levels.

Origin & History

Natural habitat

Allulose is a rare sugar found in small quantities in foods like figs, raisins, and maple syrup. It is produced commercially through a process that converts fructose from corn or other plant sources into allulose using enzymatic reactions.

“Allulose was first identified in wheat over 70 years ago but has only recently gained attention as a low-calorie sweetener. Its rise in popularity is due to increasing demand for sugar alternatives.”Traditional Medicine

Research Narrative (Provisional)

Research, including human trials, supports allulose's benefits in managing blood sugar and weight. Animal studies have shown its potential in reducing liver fat and improving lipid profiles.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Contains approximately 0.2 kcal per gram. - Does not impact blood sugar levels. - Has a glycemic index of zero.

Reported Mechanism (Provisional)

Mechanism of Action

Allulose is poorly absorbed in the small intestine, with approximately 70% excreted unchanged in urine within 24 hours. Unlike glucose, it does not undergo phosphorylation by hexokinase, preventing entry into glycolysis and subsequent ATP production. The remaining absorbed allulose may inhibit hepatic glucose production through modulation of gluconeogenic enzymes.

Clinical Narrative (Provisional)

Human studies demonstrate allulose reduces postprandial glucose and insulin responses by 20-30% compared to sucrose in doses of 5-10g. A 12-week randomized controlled trial with 121 participants showed 7.5g daily allulose reduced body fat by 1.1kg versus placebo. Additional studies indicate improved glucose tolerance and reduced HbA1c in prediabetic individuals, though long-term data remains limited.

Also Known As

D-PsicoseD-allulosePseudo-fructoseC6H12O6Rare sugarD-ribo-2-hexulose

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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