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Immune System Support: 12 Provisional Discovery Profiles

An automated discovery list of publication-gated profiles associated with immune system support. Ordering uses condition-match signals and public score. The list is provisional, has not completed accountable human review, and is not a treatment or purchase recommendation.

Data baseline audited: 2026-07-11 · Ranking method: provisional public score + condition-match signals · Pattern set: Alligator Apple, Almond Mushroom, Amazonian Guava and 9 more

The Short Answer

This automated discovery list currently places Alligator Apple, Almond Mushroom, Amazonian Guava first for immune system support. Ordering uses condition-match signals, provisional public score, screened PMID depth, and recognized ingredient data. It does not identify the “best” supplements or establish efficacy, safety, or suitability; inspect each profile's review state and supported fields.

Immune System Support ingredient profiles: provisional comparison

Use this table to compare public ranking signals, then open each profile to inspect its review state, supported fields, safety context, and screened citation mappings.

RankSupplementMatched termsPublic score stateScreened PMIDs
#1Alligator Appleimmun, antimicrobialValidated score 10/106
#2Almond Mushroomimmun, antiviral, beta-glucanValidated score 10/1010
#3Amazonian Guavaimmun, antimicrobialValidated score 10/101
#4Andrographisimmun, antiviral, infectValidated score 10/101
#5Arctic Cranberryimmun, pathogen, infectValidated score 10/106
#6Bael Leafimmun, antimicrobialValidated score 10/1010
#72'-Fucosyllactose (2'-FL)immun, pathogen, infectValidated score 8.5/103
#8AHCC (Active Hexose Correlated Compound)immun, NK cell, infectValidated score 8/100
  1. 1
    Alligator Apple
    Fruit · 6 screened PMID mappings · matches: immun, antimicrobial

    Validated profile summary: Alligator Apple (Annona glabra) is a tropical fruit of the Annonaceae family containing annonaceous acetogenins (notably annonacin), ent-kaurane diterpenoids, polyphenols, and flav…

    Validated score 10/10
  2. 2
    Almond Mushroom
    Mushroom/Fungi · 10 screened PMID mappings · matches: immun, antiviral, beta-glucan, T-cell

    Validated profile summary: Almond Mushroom (Agaricus subrufescens) is a medicinal basidiomycete rich in β-glucans, ergosterol, and polysaccharide–protein complexes that activate innate immunity by binding co…

    Validated score 10/10
  3. 3
    Amazonian Guava
    Fruit · 1 screened PMID mapping · matches: immun, antimicrobial

    Validated profile summary: Amazonian Guava (Psidium guajava), whose Amazonian origin was definitively confirmed through genomic dispersal modeling across wild populations (Arévalo-Marín et al., 2024; PMID: 3…

    Validated score 10/10
  4. 4
    Andrographis
    Herb · 1 screened PMID mapping · matches: immun, antiviral, infect

    Validated profile summary: Andrographis paniculata inhibits inflammation through andrographolide's suppression of NF-κB transcriptional activity, reducing pro-inflammatory cytokines TNF-α and IL-6 with IC₅₀ …

    Validated score 10/10
  5. 5
    Arctic Cranberry
    Fruit · 6 screened PMID mappings · matches: immun, pathogen, infect

    Validated profile summary: Arctic cranberry (Vaccinium oxycoccos and related Vaccinium spp.) is exceptionally rich in A-type proanthocyanidins (PACs), anthocyanins, quercetin, and vitamin C that inhibit urop…

    Validated score 10/10
  6. 6
    Bael Leaf
    Leaf/Green · 10 screened PMID mappings · matches: immun, antimicrobial

    Validated profile summary: Bael leaf (Aegle marmelos) is rich in bioactive compounds—including eugenol, marmelosin, skimmianine, tannins, flavonoids, and coumarins—that inhibit pro-inflammatory cytokines IL-…

    Validated score 10/10
  7. 7
    2'-Fucosyllactose (2'-FL)
    Fermented/Probiotic · 3 screened PMID mappings · matches: immun, pathogen, infect

    Validated profile summary: 2'-Fucosyllactose (2'-FL) is a human milk oligosaccharide that acts as a prebiotic by selectively feeding beneficial gut bacteria. It enhances immune function and gut health throug…

    Validated score 8.5/10
  8. 8
    AHCC (Active Hexose Correlated Compound)
    Mushroom/Fungi · matches: immun, NK cell, infect

    Validated profile summary: AHCC (Active Hexose Correlated Compound) is a standardized extract from shiitake mushrooms containing alpha-glucans that enhance immune function. It works by increasing natural kil…

    Validated score 8/10
  9. 9
    Andrographis Paniculata
    Other · 3 screened PMID mappings · matches: immun, antiviral, white blood cell, pathogen…

    Validated profile summary: Andrographis paniculata is a bitter herb containing andrographolide, which enhances immune function by activating macrophages and natural killer cells. The plant demonstrates poten…

    Validated score 8/10
  10. 10
    Acerola Cherry
    Fruit · 3 screened PMID mappings · matches: immun, white blood cell, infect

    Validated profile summary: Acerola cherry contains exceptionally high concentrations of vitamin C (up to 4,000mg per 100g) and polyphenolic compounds that support immune function and cellular antioxidant def…

    Validated score 7/10
  11. 11
    Agaricus Blazei Mushroom (Agaricus subrufescens)
    Mushroom/Fungi · 3 screened PMID mappings · matches: immun, beta-glucan, NK cell

    Validated profile summary: Agaricus blazei mushroom contains beta-glucans that activate immune cells including macrophages and NK cells to enhance immune surveillance. This medicinal mushroom modulates cytok…

    Validated score 7/10
  12. 12
    Aloe Vera Juice
    Other · 3 screened PMID mappings · matches: immun

    Validated profile summary: Aloe vera juice contains acemannan and other polysaccharides that activate immune system macrophages while soothing gastrointestinal mucosa through anti-inflammatory compounds like…

    Validated score 7/10

How this provisional order is generated

This is a transparent discovery list. Rankings are generated from the Hermetica ingredient graph, provisional public scores, screened PMID mappings, and condition-pattern matching. Rank does not prove efficacy, safety, or human review.

MethodologyReview the evidence systemEditorial teamReview the evidence systemLab-test standardsReview the evidence systemLatest researchReview the evidence system

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Frequently asked

What does this immune system support profile list show?
It shows publication-gated profiles associated with immune system support by automated condition-match and public-score signals: Alligator Apple, Almond Mushroom, Amazonian Guava, Andrographis, Arctic Cranberry, Bael Leaf, 2'-Fucosyllactose (2'-FL), AHCC (Active Hexose Correlated Compound), Andrographis Paniculata, Acerola Cherry, Agaricus Blazei Mushroom (Agaricus subrufescens), Aloe Vera Juice. It is a discovery index, not a clinical ranking. Review state and supported fields vary by profile.
Does the first profile have the strongest clinical evidence for immune system support?
No. Alligator Apple appears first by condition-match signals and provisional public score, with 6 screened PMID mappings. That order does not establish clinical efficacy, comparative superiority, or validated evidence.
How were these ingredients ranked?
Each public profile is ranked by condition-pattern matching, normalized public score, entity recognition, and presentation signals. Validation status is separate from stack order.

Other condition stacks

These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.