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Longevity & Anti-Aging: 12 Provisional Discovery Profiles

An automated discovery list of publication-gated profiles associated with longevity. Ordering uses condition-match signals and public score. The list is provisional, has not completed accountable human review, and is not a treatment or purchase recommendation.

Data baseline audited: 2026-07-11 · Ranking method: provisional public score + condition-match signals · Pattern set: Alligator Apple, Almond Mushroom, Amazonian Guaraná and 9 more

The Short Answer

This automated discovery list currently places Alligator Apple, Almond Mushroom, Amazonian Guaraná first for longevity. Ordering uses condition-match signals, provisional public score, screened PMID depth, and recognized ingredient data. It does not identify the “best” supplements or establish efficacy, safety, or suitability; inspect each profile's review state and supported fields.

Longevity & Anti-Aging ingredient profiles: provisional comparison

Use this table to compare public ranking signals, then open each profile to inspect its review state, supported fields, safety context, and screened citation mappings.

RankSupplementMatched termsPublic score stateScreened PMIDs
#1Alligator Appleaging, NADValidated score 10/106
#2Almond Mushroomlongev, aging, anti-agingValidated score 10/1010
#3Amazonian GuaranálongevValidated score 10/1010
#4Arctic Cranberrylongev, lifespanValidated score 10/106
#55-Alpha ReductaseNADValidated score 9/103
#6Algal Oil (DHA-Rich)agingValidated score 8.5/103
#7Astaxanthin (Haematococcus pluvialis)agingValidated score 8.5/108
#8Allulose (D-Psicose)agingValidated score 8/103
  1. 1
    Alligator Apple
    Fruit · 6 screened PMID mappings · matches: aging, NAD

    Validated profile summary: Alligator Apple (Annona glabra) is a tropical fruit of the Annonaceae family containing annonaceous acetogenins (notably annonacin), ent-kaurane diterpenoids, polyphenols, and flav…

    Validated score 10/10
  2. 2
    Almond Mushroom
    Mushroom/Fungi · 10 screened PMID mappings · matches: longev, aging, anti-aging

    Validated profile summary: Almond Mushroom (Agaricus subrufescens) is a medicinal basidiomycete rich in β-glucans, ergosterol, and polysaccharide–protein complexes that activate innate immunity by binding co…

    Validated score 10/10
  3. 3
    Amazonian Guaraná
    Seed · 10 screened PMID mappings · matches: longev

    Validated profile summary: Amazonian guaraná (Paullinia cupana) delivers sustained cognitive and metabolic benefits primarily through its methylxanthines—caffeine (guaranine), theobromine, and theophylline—w…

    Validated score 10/10
  4. 4
    Arctic Cranberry
    Fruit · 6 screened PMID mappings · matches: longev, lifespan

    Validated profile summary: Arctic cranberry (Vaccinium oxycoccos and related Vaccinium spp.) is exceptionally rich in A-type proanthocyanidins (PACs), anthocyanins, quercetin, and vitamin C that inhibit urop…

    Validated score 10/10
  5. 5
    5-Alpha Reductase
    Enzyme · 3 screened PMID mappings · matches: NAD

    Validated profile summary: 5-alpha reductase is an enzyme that converts testosterone to dihydrotestosterone (DHT), playing a crucial role in androgen metabolism. Inhibiting this enzyme helps reduce DHT level…

    Validated score 9/10
  6. 6
    Algal Oil (DHA-Rich)
    Other · 3 screened PMID mappings · matches: aging

    Validated profile summary: Algal oil is a plant-based omega-3 supplement that provides docosahexaenoic acid (DHA), typically containing 300-1000mg per serving. DHA incorporates into cell membranes where it m…

    Validated score 8.5/10
  7. 7
    Astaxanthin (Haematococcus pluvialis)
    Compound · 8 screened PMID mappings · matches: aging

    Validated profile summary: Astaxanthin from Haematococcus pluvialis is a potent carotenoid antioxidant that crosses the blood-brain and blood-retina barriers. It reduces oxidative stress through singlet oxyg…

    Validated score 8.5/10
  8. 8
    Allulose (D-Psicose)
    Other · 3 screened PMID mappings · matches: aging

    Validated profile summary: Allulose is a rare sugar that provides sweetness without calories while maintaining stable blood glucose levels. This monosaccharide bypasses normal glucose metabolism pathways, of…

    Validated score 8/10
  9. 9
    Alpha-Lipoic Acid (R-ALA)
    Other · 3 screened PMID mappings · matches: aging

    Validated profile summary: Alpha-lipoic acid is a unique antioxidant compound that functions in both water and fat-soluble environments throughout the body. R-ALA, the naturally occurring form, enhances insu…

    Validated score 8/10
  10. 10
    affron (Saffron Extract, 3.5% Lepticrosalides)
    Other · 8 screened PMID mappings · matches: longev

    Validated profile summary: Affron is a standardized saffron extract containing 3.5% lepticrosalides that supports mood regulation through serotonin pathway modulation. Clinical studies demonstrate up to 50% …

    Validated score 7.5/10
  11. 11
    Almond Oil
    Leaf/Green · 10 screened PMID mappings · matches: aging

    Validated profile summary: Almond oil is rich in oleic acid (62–86%), linoleic acid (6–37%), and α-tocopherol (vitamin E, 9.99–19.42 mg/100g), which collectively deliver potent anti-inflammatory, skin barrie…

    Validated score 7.5/10
  12. 12
    Aruj Leaf
    Fruit · 2 screened PMID mappings · matches: NAD

    Validated profile summary: Aruj leaf is a regional folk name for guava leaf (Psidium guajava L.), whose principal polyphenols—quercetin, gallic acid, and catechin—neutralize reactive oxygen species via pheno…

    Validated score 7.5/10

How this provisional order is generated

This is a transparent discovery list. Rankings are generated from the Hermetica ingredient graph, provisional public scores, screened PMID mappings, and condition-pattern matching. Rank does not prove efficacy, safety, or human review.

MethodologyReview the evidence systemEditorial teamReview the evidence systemLab-test standardsReview the evidence systemLatest researchReview the evidence system

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Frequently asked

What does this longevity profile list show?
It shows publication-gated profiles associated with longevity by automated condition-match and public-score signals: Alligator Apple, Almond Mushroom, Amazonian Guaraná, Arctic Cranberry, 5-Alpha Reductase, Algal Oil (DHA-Rich), Astaxanthin (Haematococcus pluvialis), Allulose (D-Psicose), Alpha-Lipoic Acid (R-ALA), affron (Saffron Extract, 3.5% Lepticrosalides), Almond Oil, Aruj Leaf. It is a discovery index, not a clinical ranking. Review state and supported fields vary by profile.
Does the first profile have the strongest clinical evidence for longevity?
No. Alligator Apple appears first by condition-match signals and provisional public score, with 6 screened PMID mappings. That order does not establish clinical efficacy, comparative superiority, or validated evidence.
How were these ingredients ranked?
Each public profile is ranked by condition-pattern matching, normalized public score, entity recognition, and presentation signals. Validation status is separate from stack order.

Other condition stacks

These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.