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Sleep & Relaxation: 12 Provisional Discovery Profiles

An automated discovery list of publication-gated profiles associated with sleep. Ordering uses condition-match signals and public score. The list is provisional, has not completed accountable human review, and is not a treatment or purchase recommendation.

Data baseline audited: 2026-07-11 · Ranking method: provisional public score + condition-match signals · Pattern set: Arrowhead Root (Sagittaria latifolia), Adenosine, Ashwagandha (Withania somnifera) and 9 more

The Short Answer

This automated discovery list currently places Arrowhead Root (Sagittaria latifolia), Adenosine, Ashwagandha (Withania somnifera) first for sleep. Ordering uses condition-match signals, provisional public score, screened PMID depth, and recognized ingredient data. It does not identify the “best” supplements or establish efficacy, safety, or suitability; inspect each profile's review state and supported fields.

Sleep & Relaxation ingredient profiles: provisional comparison

Use this table to compare public ranking signals, then open each profile to inspect its review state, supported fields, safety context, and screened citation mappings.

RankSupplementMatched termsPublic score stateScreened PMIDs
#1Arrowhead Root (Sagittaria latifolia)relaxatValidated score 10/1010
#2AdenosinesleepValidated score 9/103
#3Ashwagandha (Withania somnifera)sleep, GABAValidated score 8.5/103
#4Asgand (Withania somnifera)sleep, circadian, GABAValidated score 8/105
#55-Hydroxytryptophan (5-HTP)sleep, melatonin, restfulValidated score 7.5/103
#6Almond OilsleepValidated score 7.5/1010
#7Ashwagandha TeaGABA, calmingValidated score 7.5/1010
#8AdrafinilGABAValidated score 7/103
  1. 1
    Arrowhead Root (Sagittaria latifolia)
    Root/Rhizome · 10 screened PMID mappings · matches: relaxat

    Validated profile summary: Arrowhead Root (Sagittaria latifolia) is a nutrient-dense aquatic tuber rich in complex starches, dietary fiber, potassium, and magnesium that supports digestive health, sustained …

    Validated score 10/10
  2. 2
    Adenosine
    Compound · 3 screened PMID mappings · matches: sleep

    Validated profile summary: Adenosine is a naturally occurring nucleoside that binds to adenosine receptors (A1, A2A, A2B, A3) throughout the body. It primarily regulates cardiovascular function, sleep-wake c…

    Validated score 9/10
  3. 3
    Ashwagandha (Withania somnifera)
    Herb · 3 screened PMID mappings · matches: sleep, GABA

    Validated profile summary: Ashwagandha (Withania somnifera) contains withanolides that modulate the hypothalamic-pituitary-adrenal (HPA) axis to reduce cortisol levels and combat stress. This adaptogenic her…

    Validated score 8.5/10
  4. 4
    Asgand (Withania somnifera)
    Middle Eastern · 5 screened PMID mappings · matches: sleep, circadian, GABA, restful

    Validated profile summary: Ashwagandha (Withania somnifera) is an adaptogenic herb containing withanolides that regulate the hypothalamic-pituitary-adrenal (HPA) axis. It reduces cortisol levels by up to 30%…

    Validated score 8/10
  5. 5
    5-Hydroxytryptophan (5-HTP)
    Compound · 3 screened PMID mappings · matches: sleep, melatonin, restful

    Validated profile summary: 5-Hydroxytryptophan (5-HTP) is an amino acid derivative that directly converts to serotonin in the brain, bypassing the rate-limiting enzyme tryptophan hydroxylase. This mechanism …

    Validated score 7.5/10
  6. 6
    Almond Oil
    Leaf/Green · 10 screened PMID mappings · matches: sleep

    Validated profile summary: Almond oil is rich in oleic acid (62–86%), linoleic acid (6–37%), and α-tocopherol (vitamin E, 9.99–19.42 mg/100g), which collectively deliver potent anti-inflammatory, skin barrie…

    Validated score 7.5/10
  7. 7
    Ashwagandha Tea
    Root/Rhizome · 10 screened PMID mappings · matches: GABA, calming

    Validated profile summary: Ashwagandha tea delivers bioactive withanolides that modulate the HPA axis, activate GABA-A receptors, and upregulate BDNF to reduce cortisol, ease anxiety, and enhance cognitive f…

    Validated score 7.5/10
  8. 8
    Adrafinil
    Other · 3 screened PMID mappings · matches: GABA

    Validated profile summary: Adrafinil is a synthetic eugeroic compound that promotes wakefulness by converting to modafinil in the liver via hydrolysis. It enhances alertness and cognitive function by increas…

    Validated score 7/10
  9. 9
    Ajwain
    Spice · 2 screened PMID mappings · matches: relaxat

    Validated profile summary: Ajwain (Trachyspermum ammi) is an aromatic seed spice containing 29.20-54.5% thymol in its essential oil, which disrupts bacterial cell membranes and provides antimicrobial effects…

    Validated score 6.5/10
  10. 10
    Asiatic Pennywort
    Leaf/Green · 2 screened PMID mappings · matches: calming

    Validated profile summary: No additional key facts regarding Asiatic Pennywort (Leaf/Green) were identified from the provided competitor content, as Examine.com explicitly states 'No competitor data availabl…

    Validated score 6.5/10
  11. 11
    Andean Tarwi Bean
    Legume · 1 screened PMID mapping · matches: GABA

    Validated profile summary: Andean Tarwi Bean (Lupinus mutabilis) contains specialized conglutins proteins, with γ-conglutins improving glucose uptake and insulin regulation for anti-diabetic effects. This an…

    Validated score 6/10
  12. 12
    Anthocyanins from Tart Cherries
    Nut · 3 screened PMID mappings · matches: sleep, melatonin

    Validated profile summary: Tart cherry anthocyanins, primarily cyanidin-3-glucosyl-rutinoside, activate the Nrf2/ARE antioxidant pathway and inhibit NF-κB inflammatory signaling. These polyphenolic compounds…

    Validated score 6/10

How this provisional order is generated

This is a transparent discovery list. Rankings are generated from the Hermetica ingredient graph, provisional public scores, screened PMID mappings, and condition-pattern matching. Rank does not prove efficacy, safety, or human review.

MethodologyReview the evidence systemEditorial teamReview the evidence systemLab-test standardsReview the evidence systemLatest researchReview the evidence system

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Frequently asked

What does this sleep profile list show?
It shows publication-gated profiles associated with sleep by automated condition-match and public-score signals: Arrowhead Root (Sagittaria latifolia), Adenosine, Ashwagandha (Withania somnifera), Asgand (Withania somnifera), 5-Hydroxytryptophan (5-HTP), Almond Oil, Ashwagandha Tea, Adrafinil, Ajwain, Asiatic Pennywort, Andean Tarwi Bean, Anthocyanins from Tart Cherries. It is a discovery index, not a clinical ranking. Review state and supported fields vary by profile.
Does the first profile have the strongest clinical evidence for sleep?
No. Arrowhead Root (Sagittaria latifolia) appears first by condition-match signals and provisional public score, with 10 screened PMID mappings. That order does not establish clinical efficacy, comparative superiority, or validated evidence.
How were these ingredients ranked?
Each public profile is ranked by condition-pattern matching, normalized public score, entity recognition, and presentation signals. Validation status is separate from stack order.

Other condition stacks

These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.