Hermetica Superfood Encyclopedia
Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.
Review flags: AWAITING_SEMANTIC_VALIDATION
Alpha-linolenic acid (ALA) is an essential omega-3 fatty acid that serves as a precursor to EPA and DHA, supporting cardiovascular health through anti-inflammatory pathways. It activates PPAR-alpha receptors and influences eicosanoid production to reduce inflammation and improve lipid profiles.
Reported Benefits (Provisional)
Origin & History
ALA, or alpha-linolenic acid, is an omega-3 fatty acid found in plant sources such as flaxseeds, chia seeds, and walnuts. It is extracted through cold-pressing methods to preserve its nutritional integrity.
Research Narrative (Provisional)
Several studies, including meta-analyses, have demonstrated ALA's role in supporting heart health and reducing inflammation. Its conversion to EPA and DHA in the body is limited but beneficial.
Preparation & Dosage
Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.
Nutritional Profile
- Rich in omega-3 fatty acids, particularly ALA. - Contains essential fatty acids for overall health. - Often found in plant-based sources like flaxseeds and chia seeds.
Reported Mechanism (Provisional)
ALA activates peroxisome proliferator-activated receptor-alpha (PPAR-α) in liver cells, enhancing fatty acid oxidation and reducing triglyceride synthesis. It competitively inhibits delta-6 desaturase, reducing pro-inflammatory arachidonic acid metabolism while promoting anti-inflammatory eicosanoid production. ALA also converts to EPA and DHA at rates of 5-10% and 2-5% respectively, contributing to membrane fluidity and neuroprotective signaling.
Clinical Narrative (Provisional)
Meta-analyses of randomized controlled trials involving over 15,000 participants demonstrate ALA supplementation reduces LDL cholesterol by 6-10% at doses of 2-6g daily. A 14-year prospective study of 76,000 women found higher ALA intake associated with 14% reduced coronary heart disease risk. However, conversion efficiency to EPA/DHA varies significantly between individuals, and direct cardiovascular outcome studies show mixed results compared to marine omega-3s.
Also Known As
Research updates — and 25% off your first order
Join our list for source-aware wellness education, review-state updates, and product news — and unlock 25% off your first Hermetica order. Educational content is not medical advice. No spam, unsubscribe anytime.