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Stress & Cortisol: 12 Provisional Discovery Profiles

An automated discovery list of publication-gated profiles associated with stress. Ordering uses condition-match signals and public score. The list is provisional, has not completed accountable human review, and is not a treatment or purchase recommendation.

Data baseline audited: 2026-07-11 · Ranking method: provisional public score + condition-match signals · Pattern set: African Baobab Nut, African Nutmeg, Almond Mushroom and 9 more

The Short Answer

This automated discovery list currently places African Baobab Nut, African Nutmeg, Almond Mushroom first for stress. Ordering uses condition-match signals, provisional public score, screened PMID depth, and recognized ingredient data. It does not identify the “best” supplements or establish efficacy, safety, or suitability; inspect each profile's review state and supported fields.

Stress & Cortisol ingredient profiles: provisional comparison

Use this table to compare public ranking signals, then open each profile to inspect its review state, supported fields, safety context, and screened citation mappings.

RankSupplementMatched termsPublic score stateScreened PMIDs
#1African Baobab NutstressValidated score 10/101
#2African Nutmegstress, adaptogen, anxietyValidated score 10/1010
#3Almond Mushroomstress, adaptogenValidated score 10/1010
#4Amazonian Guaranástress, nervouValidated score 10/1010
#5Arctic CranberrystressValidated score 10/106
#6Arctic Seaberrystress, adaptogenValidated score 10/101
#7Avocado Seed FlourstressValidated score 10/101
#8Acai Palm HeartsstressValidated score 9/101
  1. 1
    African Baobab Nut
    Nut · 1 screened PMID mapping · matches: stress

    Validated profile summary: African Baobab Nut (Adansonia digitata) seeds are rich in polyphenolic compounds—including epicatechin, EGCG, and procyanidins—that activate AMPK/PI3K-Akt insulin-signaling pathway…

    Validated score 10/10
  2. 2
    African Nutmeg
    Seed · 10 screened PMID mappings · matches: stress, adaptogen, anxiety

    Validated profile summary: African nutmeg (Monodora myristica) contains bioactive compounds including myristicin, eugenol, elemicin, and limonene that demonstrate significant antioxidant, antibacterial, and …

    Validated score 10/10
  3. 3
    Almond Mushroom
    Mushroom/Fungi · 10 screened PMID mappings · matches: stress, adaptogen

    Validated profile summary: Almond Mushroom (Agaricus subrufescens) is a medicinal basidiomycete rich in β-glucans, ergosterol, and polysaccharide–protein complexes that activate innate immunity by binding co…

    Validated score 10/10
  4. 4
    Amazonian Guaraná
    Seed · 10 screened PMID mappings · matches: stress, nervou

    Validated profile summary: Amazonian guaraná (Paullinia cupana) delivers sustained cognitive and metabolic benefits primarily through its methylxanthines—caffeine (guaranine), theobromine, and theophylline—w…

    Validated score 10/10
  5. 5
    Arctic Cranberry
    Fruit · 6 screened PMID mappings · matches: stress

    Validated profile summary: Arctic cranberry (Vaccinium oxycoccos and related Vaccinium spp.) is exceptionally rich in A-type proanthocyanidins (PACs), anthocyanins, quercetin, and vitamin C that inhibit urop…

    Validated score 10/10
  6. 6
    Arctic Seaberry
    Berry · 1 screened PMID mapping · matches: stress, adaptogen

    Validated profile summary: Arctic Seaberry (Hippophae rhamnoides) contains exceptionally high concentrations of isorhamnetin, quercetin, omega-7 fatty acids, and vitamin C that modulate PI3K/AKT/mTOR and Nrf…

    Validated score 10/10
  7. 7
    Avocado Seed Flour
    Seed · 1 screened PMID mapping · matches: stress

    Validated profile summary: Avocado Seed Flour is a powdered ingredient derived from Persea americana seeds containing high concentrations of phenolic compounds (30.80 GAE/100g), flavonoids, and condensed tan…

    Validated score 10/10
  8. 8
    Acai Palm Hearts
    Other · 1 screened PMID mapping · matches: stress

    Validated profile summary: Acai palm hearts (Euterpe oleracea) contain polyphenolic compounds including anthocyanins like cyanidin-3-O-glucoside that provide antioxidant activity through Nrf2 pathway upregul…

    Validated score 9/10
  9. 9
    African Black Soap Nut
    Nut · 1 screened PMID mapping · matches: stress, calm

    Validated profile summary: The term 'African Black Soap Nut' combines elements of traditional West African black soap and soap nuts (Sapindus mukorossi), which contain 6-10% triterpenoid saponins by mass wei…

    Validated score 9/10
  10. 10
    Ashwagandha (Withania somnifera)
    Herb · 3 screened PMID mappings · matches: stress, cortisol, adaptogen, anxiety…

    Validated profile summary: Ashwagandha (Withania somnifera) contains withanolides that modulate the hypothalamic-pituitary-adrenal (HPA) axis to reduce cortisol levels and combat stress. This adaptogenic her…

    Validated score 8.5/10
  11. 11
    Astaxanthin (Haematococcus pluvialis)
    Compound · 8 screened PMID mappings · matches: stress

    Validated profile summary: Astaxanthin from Haematococcus pluvialis is a potent carotenoid antioxidant that crosses the blood-brain and blood-retina barriers. It reduces oxidative stress through singlet oxyg…

    Validated score 8.5/10
  12. 12
    Alpha-Lipoic Acid (R-ALA)
    Other · 3 screened PMID mappings · matches: stress

    Validated profile summary: Alpha-lipoic acid is a unique antioxidant compound that functions in both water and fat-soluble environments throughout the body. R-ALA, the naturally occurring form, enhances insu…

    Validated score 8/10

How this provisional order is generated

This is a transparent discovery list. Rankings are generated from the Hermetica ingredient graph, provisional public scores, screened PMID mappings, and condition-pattern matching. Rank does not prove efficacy, safety, or human review.

MethodologyReview the evidence systemEditorial teamReview the evidence systemLab-test standardsReview the evidence systemLatest researchReview the evidence system

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Frequently asked

What does this stress profile list show?
It shows publication-gated profiles associated with stress by automated condition-match and public-score signals: African Baobab Nut, African Nutmeg, Almond Mushroom, Amazonian Guaraná, Arctic Cranberry, Arctic Seaberry, Avocado Seed Flour, Acai Palm Hearts, African Black Soap Nut, Ashwagandha (Withania somnifera), Astaxanthin (Haematococcus pluvialis), Alpha-Lipoic Acid (R-ALA). It is a discovery index, not a clinical ranking. Review state and supported fields vary by profile.
Does the first profile have the strongest clinical evidence for stress?
No. African Baobab Nut appears first by condition-match signals and provisional public score, with 1 screened PMID mappings. That order does not establish clinical efficacy, comparative superiority, or validated evidence.
How were these ingredients ranked?
Each public profile is ranked by condition-pattern matching, normalized public score, entity recognition, and presentation signals. Validation status is separate from stack order.

Other condition stacks

These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.