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Mood & Emotional Wellbeing: 12 Provisional Discovery Profiles

An automated discovery list of publication-gated profiles associated with mood. Ordering uses condition-match signals and public score. The list is provisional, has not completed accountable human review, and is not a treatment or purchase recommendation.

Data baseline audited: 2026-07-11 · Ranking method: provisional public score + condition-match signals · Pattern set: African Nutmeg, Almond Mushroom, Amazonian Guaraná and 9 more

The Short Answer

This automated discovery list currently places African Nutmeg, Almond Mushroom, Amazonian Guaraná first for mood. Ordering uses condition-match signals, provisional public score, screened PMID depth, and recognized ingredient data. It does not identify the “best” supplements or establish efficacy, safety, or suitability; inspect each profile's review state and supported fields.

Mood & Emotional Wellbeing ingredient profiles: provisional comparison

Use this table to compare public ranking signals, then open each profile to inspect its review state, supported fields, safety context, and screened citation mappings.

RankSupplementMatched termsPublic score stateScreened PMIDs
#1African NutmegmoodValidated score 10/1010
#2Almond MushroomemotionalValidated score 10/1010
#3Amazonian GuaranádopamineValidated score 10/1010
#45-Alpha ReductasemoodValidated score 9/103
#5Ayahuasca Vinemood, depress, serotoninValidated score 9/101
#6Algal Oil (DHA-Rich)mood, depress, serotoninValidated score 8.5/103
#7Anchovy OilmoodValidated score 8.5/108
#8Ashwagandha (Withania somnifera)serotonin, dopamine, emotionalValidated score 8.5/103
  1. 1
    African Nutmeg
    Seed · 10 screened PMID mappings · matches: mood

    Validated profile summary: African nutmeg (Monodora myristica) contains bioactive compounds including myristicin, eugenol, elemicin, and limonene that demonstrate significant antioxidant, antibacterial, and …

    Validated score 10/10
  2. 2
    Almond Mushroom
    Mushroom/Fungi · 10 screened PMID mappings · matches: emotional

    Validated profile summary: Almond Mushroom (Agaricus subrufescens) is a medicinal basidiomycete rich in β-glucans, ergosterol, and polysaccharide–protein complexes that activate innate immunity by binding co…

    Validated score 10/10
  3. 3
    Amazonian Guaraná
    Seed · 10 screened PMID mappings · matches: dopamine

    Validated profile summary: Amazonian guaraná (Paullinia cupana) delivers sustained cognitive and metabolic benefits primarily through its methylxanthines—caffeine (guaranine), theobromine, and theophylline—w…

    Validated score 10/10
  4. 4
    5-Alpha Reductase
    Enzyme · 3 screened PMID mappings · matches: mood

    Validated profile summary: 5-alpha reductase is an enzyme that converts testosterone to dihydrotestosterone (DHT), playing a crucial role in androgen metabolism. Inhibiting this enzyme helps reduce DHT level…

    Validated score 9/10
  5. 5
    Ayahuasca Vine
    Other · 1 screened PMID mapping · matches: mood, depress, serotonin, emotional

    Validated profile summary: Banisteriopsis caapi contains β-carboline alkaloids (harmine, harmaline, tetrahydroharmine) that act as reversible MAO-A inhibitors, enabling oral DMT activation in traditional aya…

    Validated score 9/10
  6. 6
    Algal Oil (DHA-Rich)
    Other · 3 screened PMID mappings · matches: mood, depress, serotonin, dopamine…

    Validated profile summary: Algal oil is a plant-based omega-3 supplement that provides docosahexaenoic acid (DHA), typically containing 300-1000mg per serving. DHA incorporates into cell membranes where it m…

    Validated score 8.5/10
  7. 7
    Anchovy Oil
    Marine-Derived · 8 screened PMID mappings · matches: mood

    Validated profile summary: Anchovy oil is a concentrated marine lipid extract rich in EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), long-chain omega-3 fatty acids that support cardiovascular an…

    Validated score 8.5/10
  8. 8
    Ashwagandha (Withania somnifera)
    Herb · 3 screened PMID mappings · matches: serotonin, dopamine, emotional

    Validated profile summary: Ashwagandha (Withania somnifera) contains withanolides that modulate the hypothalamic-pituitary-adrenal (HPA) axis to reduce cortisol levels and combat stress. This adaptogenic her…

    Validated score 8.5/10
  9. 9
    Acetyl-L-Carnitine (ALCAR)
    Compound · 3 screened PMID mappings · matches: mood, depress, emotional

    Validated profile summary: Acetyl-L-Carnitine (ALCAR) is an acetylated form of L-carnitine that crosses the blood-brain barrier to enhance cognitive function and cellular energy production. It works by facil…

    Validated score 8/10
  10. 10
    5-Hydroxytryptophan (5-HTP)
    Compound · 3 screened PMID mappings · matches: mood, depress, serotonin, emotional

    Validated profile summary: 5-Hydroxytryptophan (5-HTP) is an amino acid derivative that directly converts to serotonin in the brain, bypassing the rate-limiting enzyme tryptophan hydroxylase. This mechanism …

    Validated score 7.5/10
  11. 11
    affron (Saffron Extract, 3.5% Lepticrosalides)
    Other · 8 screened PMID mappings · matches: mood, depress, serotonin, dopamine

    Validated profile summary: Affron is a standardized saffron extract containing 3.5% lepticrosalides that supports mood regulation through serotonin pathway modulation. Clinical studies demonstrate up to 50% …

    Validated score 7.5/10
  12. 12
    Alpha-GPC (Alpha-Glycerylphosphorylcholine)
    Other · 1 screened PMID mapping · matches: mood

    Validated profile summary: Alpha-GPC (L-alpha-glycerylphosphorylcholine) is a choline-containing phospholipid that crosses the blood-brain barrier to increase acetylcholine synthesis. It enhances cognitive f…

    Validated score 7.5/10

How this provisional order is generated

This is a transparent discovery list. Rankings are generated from the Hermetica ingredient graph, provisional public scores, screened PMID mappings, and condition-pattern matching. Rank does not prove efficacy, safety, or human review.

MethodologyReview the evidence systemEditorial teamReview the evidence systemLab-test standardsReview the evidence systemLatest researchReview the evidence system

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Frequently asked

What does this mood profile list show?
It shows publication-gated profiles associated with mood by automated condition-match and public-score signals: African Nutmeg, Almond Mushroom, Amazonian Guaraná, 5-Alpha Reductase, Ayahuasca Vine, Algal Oil (DHA-Rich), Anchovy Oil, Ashwagandha (Withania somnifera), Acetyl-L-Carnitine (ALCAR), 5-Hydroxytryptophan (5-HTP), affron (Saffron Extract, 3.5% Lepticrosalides), Alpha-GPC (Alpha-Glycerylphosphorylcholine). It is a discovery index, not a clinical ranking. Review state and supported fields vary by profile.
Does the first profile have the strongest clinical evidence for mood?
No. African Nutmeg appears first by condition-match signals and provisional public score, with 10 screened PMID mappings. That order does not establish clinical efficacy, comparative superiority, or validated evidence.
How were these ingredients ranked?
Each public profile is ranked by condition-pattern matching, normalized public score, entity recognition, and presentation signals. Validation status is separate from stack order.

Other condition stacks

These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.