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Anxiety & Calm: 12 Provisional Discovery Profiles

An automated discovery list of publication-gated profiles associated with anxiety. Ordering uses condition-match signals and public score. The list is provisional, has not completed accountable human review, and is not a treatment or purchase recommendation.

Data baseline audited: 2026-07-11 · Ranking method: provisional public score + condition-match signals · Pattern set: African Nutmeg, Amazonian Guaraná, Adenosine and 9 more

The Short Answer

This automated discovery list currently places African Nutmeg, Amazonian Guaraná, Adenosine first for anxiety. Ordering uses condition-match signals, provisional public score, screened PMID depth, and recognized ingredient data. It does not identify the “best” supplements or establish efficacy, safety, or suitability; inspect each profile's review state and supported fields.

Anxiety & Calm ingredient profiles: provisional comparison

Use this table to compare public ranking signals, then open each profile to inspect its review state, supported fields, safety context, and screened citation mappings.

RankSupplementMatched termsPublic score stateScreened PMIDs
#1African NutmeganxietValidated score 10/1010
#2Amazonian GuaranánervouValidated score 10/1010
#3AdenosinetranquilValidated score 9/103
#4African Black Soap NutcalmValidated score 9/101
#5Ayahuasca VineserotoninValidated score 9/101
#6Algal Oil (DHA-Rich)serotoninValidated score 8.5/103
#7Ashwagandha (Withania somnifera)anxiet, GABA, serotoninValidated score 8.5/103
#8Asgand (Withania somnifera)anxiolytic, calm, GABAValidated score 8/105
  1. 1
    African Nutmeg
    Seed · 10 screened PMID mappings · matches: anxiet

    Validated profile summary: African nutmeg (Monodora myristica) contains bioactive compounds including myristicin, eugenol, elemicin, and limonene that demonstrate significant antioxidant, antibacterial, and …

    Validated score 10/10
  2. 2
    Amazonian Guaraná
    Seed · 10 screened PMID mappings · matches: nervou

    Validated profile summary: Amazonian guaraná (Paullinia cupana) delivers sustained cognitive and metabolic benefits primarily through its methylxanthines—caffeine (guaranine), theobromine, and theophylline—w…

    Validated score 10/10
  3. 3
    Adenosine
    Compound · 3 screened PMID mappings · matches: tranquil

    Validated profile summary: Adenosine is a naturally occurring nucleoside that binds to adenosine receptors (A1, A2A, A2B, A3) throughout the body. It primarily regulates cardiovascular function, sleep-wake c…

    Validated score 9/10
  4. 4
    African Black Soap Nut
    Nut · 1 screened PMID mapping · matches: calm

    Validated profile summary: The term 'African Black Soap Nut' combines elements of traditional West African black soap and soap nuts (Sapindus mukorossi), which contain 6-10% triterpenoid saponins by mass wei…

    Validated score 9/10
  5. 5
    Ayahuasca Vine
    Other · 1 screened PMID mapping · matches: serotonin

    Validated profile summary: Banisteriopsis caapi contains β-carboline alkaloids (harmine, harmaline, tetrahydroharmine) that act as reversible MAO-A inhibitors, enabling oral DMT activation in traditional aya…

    Validated score 9/10
  6. 6
    Algal Oil (DHA-Rich)
    Other · 3 screened PMID mappings · matches: serotonin

    Validated profile summary: Algal oil is a plant-based omega-3 supplement that provides docosahexaenoic acid (DHA), typically containing 300-1000mg per serving. DHA incorporates into cell membranes where it m…

    Validated score 8.5/10
  7. 7
    Ashwagandha (Withania somnifera)
    Herb · 3 screened PMID mappings · matches: anxiet, GABA, serotonin, nervou

    Validated profile summary: Ashwagandha (Withania somnifera) contains withanolides that modulate the hypothalamic-pituitary-adrenal (HPA) axis to reduce cortisol levels and combat stress. This adaptogenic her…

    Validated score 8.5/10
  8. 8
    Asgand (Withania somnifera)
    Middle Eastern · 5 screened PMID mappings · matches: anxiolytic, calm, GABA

    Validated profile summary: Ashwagandha (Withania somnifera) is an adaptogenic herb containing withanolides that regulate the hypothalamic-pituitary-adrenal (HPA) axis. It reduces cortisol levels by up to 30%…

    Validated score 8/10
  9. 9
    5-Hydroxytryptophan (5-HTP)
    Compound · 3 screened PMID mappings · matches: anxiet, calm, serotonin

    Validated profile summary: 5-Hydroxytryptophan (5-HTP) is an amino acid derivative that directly converts to serotonin in the brain, bypassing the rate-limiting enzyme tryptophan hydroxylase. This mechanism …

    Validated score 7.5/10
  10. 10
    affron (Saffron Extract, 3.5% Lepticrosalides)
    Other · 8 screened PMID mappings · matches: anxiet, serotonin

    Validated profile summary: Affron is a standardized saffron extract containing 3.5% lepticrosalides that supports mood regulation through serotonin pathway modulation. Clinical studies demonstrate up to 50% …

    Validated score 7.5/10
  11. 11
    Ashwagandha Tea
    Root/Rhizome · 10 screened PMID mappings · matches: anxiolytic, calm, GABA, nervou

    Validated profile summary: Ashwagandha tea delivers bioactive withanolides that modulate the HPA axis, activate GABA-A receptors, and upregulate BDNF to reduce cortisol, ease anxiety, and enhance cognitive f…

    Validated score 7.5/10
  12. 12
    Bacopa Monnieri (Brahmi)
    Herb · 2 screened PMID mappings · matches: anxiet, serotonin

    Validated profile summary: Bacopa monnieri contains bacosides A and B, triterpene saponins that enhance synaptic transmission and promote nerve growth factor synthesis. These compounds cross the blood-brain …

    Validated score 7.5/10

How this provisional order is generated

This is a transparent discovery list. Rankings are generated from the Hermetica ingredient graph, provisional public scores, screened PMID mappings, and condition-pattern matching. Rank does not prove efficacy, safety, or human review.

MethodologyReview the evidence systemEditorial teamReview the evidence systemLab-test standardsReview the evidence systemLatest researchReview the evidence system

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Frequently asked

What does this anxiety profile list show?
It shows publication-gated profiles associated with anxiety by automated condition-match and public-score signals: African Nutmeg, Amazonian Guaraná, Adenosine, African Black Soap Nut, Ayahuasca Vine, Algal Oil (DHA-Rich), Ashwagandha (Withania somnifera), Asgand (Withania somnifera), 5-Hydroxytryptophan (5-HTP), affron (Saffron Extract, 3.5% Lepticrosalides), Ashwagandha Tea, Bacopa Monnieri (Brahmi). It is a discovery index, not a clinical ranking. Review state and supported fields vary by profile.
Does the first profile have the strongest clinical evidence for anxiety?
No. African Nutmeg appears first by condition-match signals and provisional public score, with 10 screened PMID mappings. That order does not establish clinical efficacy, comparative superiority, or validated evidence.
How were these ingredients ranked?
Each public profile is ranked by condition-pattern matching, normalized public score, entity recognition, and presentation signals. Validation status is separate from stack order.

Other condition stacks

These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.