Evidence-Based Guide

Longevity & Anti-Aging

Compounds that target hallmarks of aging — from NAD+ precursors and senolytics to telomere-protective antioxidants.

20ingredients ranked by evidence
#1

Black Raspberry Seed Extract

Strong
Extract

Reduces signs of aging by protecting collagen, reducing inflammation, and supporting skin elasticity.

Black Raspberry Seed Extract is a extract ingredient known for delivers powerful antioxidant protection against free radicals and environmental stress...

#2

Madagascar Periwinkle Leaf

Strong
Leaf/Green

Enhances cognitive clarity, supports immune resilience, regulates blood sugar, improves circulation, reduces inflammation, promotes cellular regeneration and longevity Research further indicates that Madagascar Periwinkle Leaf may support metabolic efficiency and cellular energy production through its micronutrient and cofactor content. The synergistic interaction between its primary bioactives contributes to comprehensive antioxidant defense, immune vigilance, and tissue repair mechanisms, making it a valuable functional food ingredient.

Madagascar Periwinkle Leaf is a leaf ingredient known for enhances cognitive clarity, supports immune resilience, regulates blood sugar, improves circ...

#3

Black Raspberry Seed Extract

Strong
Extract

Reduces signs of aging by protecting collagen, reducing inflammation, and supporting skin elasticity.

Black Raspberry Seed Extract is a extract ingredient known for delivers powerful antioxidant protection against free radicals and environmental stress...

#4

Cordyceps (Cordyceps militaris & Cordyceps sinensis)

Strong
Mushroom/Fungi

Slows cellular aging and promotes longevity through potent antioxidant activity and mitochondrial protection.

Cordyceps (Cordyceps militaris & Cordyceps sinensis) is a mushroom ingredient known for boosts energy, endurance, and athletic performance by increasi...

#5

Elderberry Extract

Strong
Extract

Supports immune function by enhancing antiviral defenses and reducing inflammation, promotes respiratory health by clearing congestion and modulating inflammatory pathways, aids in cardiovascular health by improving circulation and reducing oxidative stress, strengthens metabolic function by regulating blood sugar levels and lipid metabolism, and provides powerful antioxidant protection against cellular aging and environmental toxins. Additional benefits include skin health enhancement, gut microbiome support, and cognitive function improvement.

Elderberry Extract is a berry ingredient known for supports immune function by enhancing antiviral defenses and reducing inflammation, promotes respir...

#6

Turmeric Root

Strong
Root/Rhizome

Turmeric root supports joint and cardiovascular health through its high content of curcumin, a powerful anti-inflammatory and antioxidant compound. Curcumin reduces oxidative stress, modulates inflammatory pathways, and supports endothelial function, promoting heart health by improving circulation and lowering cholesterol levels. Turmeric also boosts cognitive health by crossing the blood-brain barrier to reduce neuroinflammation, supporting memory, focus, and overall brain function. The root enhances immune resilience by modulating immune cell responses and exhibiting antimicrobial properties. Additionally, turmeric supports metabolic health by regulating blood sugar levels and enhancing insulin sensitivity, making it beneficial for individuals managing diabetes. It aids digestive health by stimulating bile production, promoting gut motility, and supporting microbiome balance. The root’s skin-protective properties, derived from its antioxidant profile, promote wound healing and combat signs of aging. Emerging research also suggests turmeric’s role in cancer prevention by inhibiting the growth of certain cancer cells and reducing tumor formation.

Turmeric Root is a root ingredient known for turmeric root supports joint and cardiovascular health through its high content of curcumin, a powerful a...

#7

Black Raspberry Seed Extract

Strong
Extract

Reduces signs of aging by protecting collagen, reducing inflammation, and supporting skin elasticity.

Black Raspberry Seed Extract is a extract ingredient known for delivers powerful antioxidant protection against free radicals and environmental stress...

#8

Guava Leaf

Strong
Leaf/Green

Promotes digestive health by stimulating gastric secretions, improving gut motility, and preventing diarrhea through antimicrobial action; Regulates blood sugar levels and improves insulin sensitivity, supporting metabolic health and reducing the risk of diabetes; Enhances skin health and collagen regeneration through vitamin C and antioxidants, improving elasticity and reducing signs of aging; Reduces inflammation and alleviates pain in conditions like arthritis and joint discomfort through flavonoids and tannins; Strengthens immune function and protects cells from oxidative stress with rich antioxidant and antimicrobial compounds; Nourishes the scalp, promotes hair growth, and reduces dandruff, improving overall hair vitality

Guava Leaf is a leaf ingredient known for promotes digestive health by stimulating gastric secretions, improving gut motility, and preventing diarrhea...

#9
Turmeric Root Extract

Turmeric Root Extract

Strong
Root/Rhizome

Provides powerful anti-inflammatory and joint health support through curcumin’s inhibition of NF-κB and COX-2 pathways, reducing pain and stiffness associated with arthritis and autoimmune conditions; delivers potent antioxidant and cellular protection by neutralizing free radicals and boosting glutathione levels, guarding against oxidative stress and premature aging; enhances cognitive function and neuroprotection by elevating BDNF (brain-derived neurotrophic factor), supporting memory, focus, and neuroplasticity while mitigating neurodegenerative risks; improves digestive and gut health by stimulating bile production, promoting microbiota balance, and reducing gastrointestinal inflammation; supports cardiovascular health by improving endothelial function, reducing LDL oxidation, and enhancing circulation; strengthens immune resilience by modulating cytokine responses and supporting gut-associated lymphoid tissue activity.

Turmeric Root Extract is a root ingredient known for provides powerful anti-inflammatory and joint health support through curcumin’s inhibition of nf-...

#10

Amalaki Berry

Strong
Fruit

Immune Resilience: Exceptionally high vitamin C content enhances immune function and white blood cell activity. Antioxidant Protection: Emblicanin A & B, gallic acid, and ellagic acid combat oxidative stress and promote healthy aging. Digestive Wellness: Stimulates gastric secretions, improves nutrient absorption, and supports gut microbiome balance. Cardiovascular Health: Regulates cholesterol, improves arterial elasticity, and supports healthy blood pressure. Cognitive Support: Antioxidants and flavonoids protect brain cells, enhance memory, and reduce neurodegenerative risks. Anti-Inflammatory Support: Reduces systemic inflammation, supporting joint and musculoskeletal health. Skin Health & Longevity: Promotes collagen synthesis, reduces signs of aging, and enhances skin vitality.

Amalaki Berry is a fruit ingredient known for immune resilience: exceptionally high vitamin c content enhances immune function and white blood cell ac...

#11

Maitake Mushroom (Grifola frondosa)

Strong
Mushroom/Fungi

Protects cells from oxidative stress with natural antioxidants, slowing aging and cellular degeneration.

Maitake Mushroom (Grifola frondosa) is a mushroom ingredient known for enhances immune system performance by activating macrophages, dendritic cells, ...

#12

Red Cabbage Leaf

Strong
Vegetable

Promotes gut and digestive health through its rich fiber and glucosinolate content that supports microbiome diversity, enhances digestion, and reduces bloating; delivers potent anti-inflammatory and cellular protection via anthocyanins and sulforaphane, reducing oxidative stress at the cellular level; supports cardiovascular and circulatory health through polyphenols and potassium that regulate blood pressure and improve arterial flexibility; strengthens immune function and detoxification pathways through high vitamin C and sulfur compounds that enhance liver cleansing and immune resilience; promotes skin health and combats aging by supporting collagen production and reducing oxidative damage through flavonoids and vitamin K.

Red Cabbage Leaf is a vegetable ingredient known for promotes gut and digestive health through its rich fiber and glucosinolate content that supports ...

#13

Reishi Mushroom (Ganoderma lucidum)

Strong
Mushroom/Fungi

Provides antioxidant protection, reducing cellular damage and supporting healthy aging.

Reishi Mushroom (Ganoderma lucidum) is a mushroom ingredient known for enhances immune function by increasing white blood cell activity and modulating...

#14

Sea Buckthorn (Hippophae rhamnoides)

Strong
Other

Delays visible signs of aging by combating oxidative stress and promoting cellular regeneration.

Sea Buckthorn (Hippophae rhamnoides) is a berry ingredient known for enhances skin hydration, elasticity, and repair through its rich omega-7 (palmito...

#15

Cordyceps Sinensis Powder

Strong
Mushroom/Fungi

Offers anti-aging benefits by reducing oxidative stress and supporting cellular regeneration.

Cordyceps Sinensis Powder is a powder ingredient known for increases energy and endurance by enhancing atp production and improving oxygen utilization...

#16

Acerola Cherry

Strong
Fruit

Immune Support and Resilience: Exceptionally high in vitamin C, boosting immune defenses, enhancing white blood cell activity, and strengthening infection response. Antioxidant and Cellular Longevity: Polyphenols, anthocyanins, and carotenoids neutralize oxidative stress, support DNA repair, and promote cellular resilience. Skin Health and Collagen Production: Bioavailable vitamin C stimulates collagen synthesis, reduces pigmentation, and improves skin elasticity. Cardiovascular and Circulatory Health: Regulates blood pressure, improves blood flow, and reduces arterial stiffness for heart vitality. Cognitive Function and Neuroprotection: Reduces oxidative stress in the brain, enhances memory retention, and supports mental clarity.

Acerola Cherry is a fruit ingredient known for immune support and resilience: exceptionally high in vitamin c, boosting immune defenses, enhancing whi...

#17

Ganoderma Lucidum (Reishi)

Strong
Mushroom/Fungi

Antioxidant Protection: Rich in triterpenoids and polyphenols that reduce oxidative stress and support cellular longevity.

Ganoderma Lucidum (Reishi) is a mushroom ingredient known for immune support: contains beta-glucans and polysaccharides that activate immune cells and...

#18

Sea Buckthorn (Hippophae rhamnoides)

Strong
Other

Delays visible signs of aging by combating oxidative stress and promoting cellular regeneration.

Sea Buckthorn (Hippophae rhamnoides) is a berry ingredient known for enhances skin hydration, elasticity, and repair through its rich omega-7 (palmito...

#19

Rosehip Seed

Strong
Seed

Skin Regeneration and Anti-Aging: Promotes hydration, elasticity, and cell regeneration; reduces appearance of scars, wrinkles, and hyperpigmentation. Joint and Inflammatory Support: Reduces inflammation and improves mobility through omega fatty acids and antioxidants. Cardiovascular Health: Supports cholesterol balance and circulation via polyunsaturated fatty acids and phytosterols. Immune Resilience: Enhances immune defenses through antioxidant-rich compounds like tocopherols and carotenoids. Digestive and Gut Health: Supports gut lining integrity and may aid in fat metabolism. Cognitive and Neuroprotection: Supports brain health and reduces cognitive decline risks via omega-3 fatty acids and antioxidants.

Rosehip Seed is a seed ingredient known for skin regeneration and anti-aging: promotes hydration, elasticity, and cell regeneration; reduces appearanc...

#20

Elderberry Extract

Strong
Extract

Supports immune function by enhancing antiviral defenses and reducing inflammation, promotes respiratory health by clearing congestion and modulating inflammatory pathways, aids in cardiovascular health by improving circulation and reducing oxidative stress, strengthens metabolic function by regulating blood sugar levels and lipid metabolism, and provides powerful antioxidant protection against cellular aging and environmental toxins. Additional benefits include skin health enhancement, gut microbiome support, and cognitive function improvement.

Elderberry Extract is a berry ingredient known for supports immune function by enhancing antiviral defenses and reducing inflammation, promotes respir...