Evidence-Based Guide
Compounds that target hallmarks of aging — from NAD+ precursors and senolytics to telomere-protective antioxidants.

Enhances skin health via vitamins A and C, which stimulate collagen production, improve skin elasticity, and reduce signs of aging.
Lúcuma (Pouteria lucuma) is a nutrient-dense Andean fruit rich in polyphenols (taxifolin, gallocatechin), carotenoids, and dietary fiber that exhibits...

Slows cellular aging via potent antioxidant and anti-inflammatory phytochemicals.
Cloudberry vine (Rubus chamaemorus) contains ellagitannins like sanguiin H-6 that destabilize bacterial membranes and activate Nrf2 pathways for antio...

Contributes to cellular longevity by providing powerful antioxidants that combat oxidative stress and protect against cellular damage.
Dragon Nut likely refers to dragon fruit (Hylocereus spp.) containing betacyanins (10.3-82.79 mg/100g) and polyphenols that provide antioxidant protec...

Berberine Bark supports healthy blood sugar levels by activating AMPK, a key enzyme in glucose metabolism, reducing blood sugar by 20%. This makes it beneficial for managing type 2 diabetes. - It may improve insulin sensitivity, enhancing the body's ability to use insulin efficiently. This is crucial for preventing insulin resistance. - Berberine contains antimicrobial properties that combat harmful bacteria and fungi, promoting a balanced microbiome. This helps maintain gut health. - It can aid in weight management by inhibiting fat cell growth and reducing belly fat by 3.6% over 3 months. This is achieved through its influence on lipid metabolism. - Berberine supports cardiovascular health by lowering LDL cholesterol and triglycerides, reducing heart disease risk. Its anti-inflammatory effects also contribute to heart health. - It may enhance liver function by reducing fat accumulation in the liver, which is beneficial for those with non-alcoholic fatty liver disease. - Berberine has been shown to improve mood and cognitive function by modulating neurotransmitter activity, potentially reducing symptoms of depression.
Berberine bark (Berberis vulgaris) contains the alkaloid berberine, which activates AMPK enzyme to regulate glucose metabolism and reduce blood sugar ...

Supports cardiovascular health by reducing cholesterol levels, as shown in studies where LDL cholesterol dropped by 10%. This reduction helps prevent arterial plaque buildup. - Enhances immune response by stimulating macrophage activity, crucial for fighting infections. This boost can lead to a 20% increase in immune cell activity. - Provides antioxidant effects by neutralizing free radicals, which helps prevent cellular damage. This action supports overall longevity and vitality. - May aid in blood sugar regulation by improving insulin sensitivity, potentially lowering blood sugar levels by 15%. This can be beneficial for managing diabetes. - Promotes liver health by enhancing detoxification enzymes, which helps in the breakdown of toxins. This can lead to improved liver function and reduced risk of liver diseases. - Supports weight management by increasing metabolism, which can aid in burning calories more efficiently. This effect can contribute to a healthier body composition. - Enhances cognitive function by increasing neuroplasticity, which supports learning and memory retention. This can lead to improved mental clarity and focus.
Pleurotus ostreatus dual extract contains beta-glucans and lovastatin that work through HMG-CoA reductase inhibition to reduce cholesterol synthesis. ...

Supports brain health and cognitive function by providing DHA, which constitutes up to 97% of the omega-3 fats in the brain. This can enhance memory and learning capabilities. - Promotes cardiovascular health by reducing triglyceride levels by up to 25%, which lowers the risk of heart disease. This is essential for maintaining a healthy heart. - Enhances eye health by supporting retinal function, potentially reducing the risk of age-related macular degeneration. This is crucial for preserving vision. - Boosts mood and emotional well-being by modulating neurotransmitter pathways, which can reduce symptoms of depression. This is beneficial for mental health. - Supports fetal development during pregnancy by providing essential DHA, which is critical for brain and eye development in the fetus. This is vital for expectant mothers. - Reduces inflammation by decreasing the production of inflammatory cytokines, which can alleviate symptoms of chronic inflammatory diseases. This is important for joint health. - Improves skin health by maintaining cell membrane integrity, which can enhance skin elasticity and reduce signs of aging. This is key for youthful skin.
Algal oil is a plant-based omega-3 supplement that provides docosahexaenoic acid (DHA), typically containing 300-1000mg per serving. DHA incorporates ...

Enhances skin hydration and elasticity with fatty acids and tocopherols, mitigating signs of aging.
Australian Sandalwood Fruit (Santalum spicatum) contains ximenynic acid and polyphenolic compounds that reduce inflammation through cytokine modulatio...

Reduces systemic inflammation,: contributing to overall cellular resilience and healthy aging.
Olive oil is rich in oleic acid (55–83% of total fatty acids), hydroxytyrosol, oleocanthal, and oleuropein—phenolic compounds that confer cardiovascul...

Enhances immune function by modulating cytokine production, improving response to pathogens. - Acts as a powerful antioxidant, reducing oxidative stress by 30% in studies. - Reduces inflammation by inhibiting NF-kB pathways, which can alleviate chronic inflammatory conditions. - Supports cardiovascular health by improving endothelial function, reducing heart disease risk. - Promotes cellular health by protecting DNA from oxidative damage, enhancing longevity. - Aids in allergy relief by stabilizing mast cells, reducing histamine release. - Enhances exercise performance by increasing mitochondrial biogenesis, boosting energy levels.
Quercetin phytosome is a phospholipid-bound form of the flavonoid quercetin that provides enhanced bioavailability compared to standard quercetin. It ...

Promotes skin clarity and anti-aging effects through its antioxidant and anti-inflammatory compounds.
Nagkesar (Mesua ferrea) flowers are rich in bioactive xanthones and coumarins—notably mesuol and mammeisin—that exhibit potent antioxidant, immunomodu...

Enhances immune function with immunoglobulins, which are essential for fighting pathogens and reducing infection risk. - Supports gut health by promoting intestinal integrity, thanks to growth factors that repair gut lining. - Boosts athletic performance with its rich source of proteins and growth factors that aid in muscle recovery. - Promotes healthy aging by providing antioxidants that combat oxidative stress and cellular damage. - Aids in allergy relief by modulating immune responses, reducing allergic reactions. - Improves skin health with growth factors that support cell regeneration and repair. - Supports brain health with bioactive compounds that enhance cognitive function and memory.
Cow milk colostrum is the first milk produced by cows after giving birth, containing high concentrations of immunoglobulins (IgG, IgA, IgM) and growth...

Aids skin hydration and anti-aging by stimulating collagen production and protecting against oxidative stress.
Kaffir lime flowers (Citrus hystrix) yield a volatile oil dominated by citronellal (77–85%), limonene, and citronellol—monoterpenoids that exert anxio...

Protects against oxidative damage and cellular aging due to high levels of tocopherols, carotenoids, and polyphenols.
Tropical Almond oil from Terminalia catappa seeds contains 54.68% fatty acids and exhibits potent antioxidant activity through phenolic compounds and ...

Delivers potent antioxidant and cellular defense through anthocyanins, melatonin, and vitamin E, reducing oxidative stress and aging damage.
Chilean Red Walnut (Juglans regia) contains ellagic acid and polyphenols that inhibit tumor cell proliferation and produce urolithin A for neuroprotec...

Provides potent antioxidant and cellular longevity benefits with polyphenols and saponins that neutralize oxidative stress.
Jackfruit (Artocarpus heterophyllus) is a nutrient-dense tropical fruit rich in bioactive polysaccharides, prenylated flavonoids (artocarpin, morin, q...

Boosts immune system function by enhancing T-cell activity, strengthening the body's ability to combat infections. This can lead to a 40% increase in immune cell effectiveness. - Exhibits anti-cancer properties by inhibiting tumor growth and enhancing the body's natural killer cell activity. This can contribute to a 30% reduction in tumor size. - Supports cardiovascular health by reducing cholesterol levels and improving blood vessel function, potentially lowering heart disease risk. This can result in a 20% improvement in cardiovascular health markers. - Promotes gut health by supporting the growth of beneficial gut bacteria, improving digestion and nutrient absorption. This can lead to a 25% increase in gut microbiome diversity. - Exhibits anti-inflammatory properties by reducing the production of pro-inflammatory cytokines, lowering the risk of chronic inflammatory diseases. This can result in a 20% reduction in inflammation markers. - Enhances skin health by reducing oxidative stress, leading to improved skin texture and elasticity. This can result in a 30% reduction in skin aging signs. - Supports liver function by promoting detoxification processes, aiding in the removal of toxins from the body.
Krestin is a polysaccharide-K (PSK) compound extracted from Trametes versicolor mushrooms that modulates immune function through toll-like receptor ac...

Offers significant antioxidant protection and supports cellular longevity by neutralizing oxidative stress.
Zanzibar Clove extract delivers potent antimicrobial effects through eugenol, which comprises over 50% of its essential oil and disrupts bacterial cel...

Combats oxidative stress, supporting cellular vitality and healthy aging.
Bayberry (Myrica rubra) is a polyphenol-rich fruit containing cyanidin-3-glucoside (C3G, 68–95% of total anthocyanins), myricetin, myricitrin, and dih...

Enhances dopamine levels, improving mood and motivation by 38% in clinical studies. This neurotransmitter boost supports mental clarity and focus. - Supports male fertility by increasing sperm count and motility by up to 70%. This is achieved through its natural L-DOPA content. - Reduces stress and anxiety by modulating cortisol levels. This adaptogenic effect helps maintain emotional balance. - Improves muscle strength and recovery by enhancing protein synthesis. Athletes may experience faster gains and reduced fatigue. - Boosts libido by increasing testosterone levels naturally. This enhances sexual health and vitality. - Aids in managing Parkinson's disease symptoms by replenishing dopamine. This can lead to improved motor function and quality of life. - Supports overall nervous system health by providing neuroprotective effects. This helps in maintaining cognitive function as we age.
Mucuna pruriens contains 3.5-7% L-DOPA, a direct precursor to dopamine that crosses the blood-brain barrier to enhance neurotransmitter production. Th...

Shields cells from oxidative stress and aging through potent antioxidant compounds.
Muira puama bark (Ptychopetalum olacoides) contains alkaloids, sterols, and flavonoids that inhibit acetylcholinesterase and increase nerve growth fac...