MODERATE — Monitor Closely
CAUTION — monitor mood
Evidence level: MODERATE
Rifampin may reduce Paxil effectiveness.
Rifampin induces CYP enzymes. May reduce paroxetine levels.
Monitor for depression/anxiety breakthrough.
Take Paroxetine and Rifampin at their usual prescribed times. Some antibiotics (linezolid especially) have serotonergic properties and should never be combined with SSRIs — if you are on linezolid, confirm this combination with your prescriber. Standard antibiotics like amoxicillin or azithromycin are generally safe alongside SSRIs.
Active depression
Worsening depression, anxiety
Coordinate between prescribers.
Discuss this combination with your prescriber. They may adjust timing, dosing, or switch to an alternative with fewer interaction risks. Never stop an antidepressant abruptly — taper under medical guidance.
Rifampin may reduce Paxil effectiveness.
Take Paroxetine and Rifampin at their usual prescribed times. Some antibiotics (linezolid especially) have serotonergic properties and should never be combined with SSRIs — if you are on linezolid, confirm this combination with your prescriber. Standard antibiotics like amoxicillin or azithromycin are generally safe alongside SSRIs.
Worsening depression, anxiety
Discuss this combination with your prescriber. They may adjust timing, dosing, or switch to an alternative with fewer interaction risks. Never stop an antidepressant abruptly — taper under medical guidance.
Coordinate between prescribers.
Or browse the full interaction database (121,000+ pairs).