MAJOR — Use With Caution
CAUTION — lorazepam is less affected than other benzos but still impacted by rifampin UGT induction
Evidence level: MODERATE
Rifampin can reduce even lorazepam levels, though less than other benzodiazepines.
Rifampin induces glucuronidation (UGT) enzymes. Lorazepam is glucuronidated. Even lorazepam may be affected, though less than CYP-dependent benzos.
Monitor for reduced benzodiazepine effect. Dose may need adjustment.
Follow each medication's specific timing instructions. Rifampin — check if it requires an empty stomach or should be taken with food. Lorazepam follows its normal schedule. Complete the full antibiotic course as prescribed.
Benzodiazepine dependence
Anxiety breakthrough, insomnia
Discuss with prescriber.
Combining sedatives increases overdose risk. Discuss with your doctor: magnesium glycinate, L-theanine, or passionflower may provide anxiety relief with fewer interaction risks. Never stop benzodiazepines abruptly — taper under medical supervision.
Rifampin can reduce even lorazepam levels, though less than other benzodiazepines.
Follow each medication's specific timing instructions. Rifampin — check if it requires an empty stomach or should be taken with food. Lorazepam follows its normal schedule. Complete the full antibiotic course as prescribed.
Anxiety breakthrough, insomnia
Combining sedatives increases overdose risk. Discuss with your doctor: magnesium glycinate, L-theanine, or passionflower may provide anxiety relief with fewer interaction risks. Never stop benzodiazepines abruptly — taper under medical supervision.
Discuss with prescriber.
Or browse the full interaction database (121,000+ pairs).