MODERATE — Monitor Closely
CAUTION — monitor mood
Evidence level: MODERATE
Rifampin may reduce Celexa effectiveness.
Rifampin induces CYP3A4 and 2C19. Citalopram metabolized by CYP2C19 and 3A4. May reduce levels.
Monitor for depression breakthrough during rifampin therapy.
Take Citalopram and Rifampin at their usual prescribed times. Some antibiotics (linezolid especially) have serotonergic properties and should never be combined with SSRIs — if you are on linezolid, confirm this combination with your prescriber. Standard antibiotics like amoxicillin or azithromycin are generally safe alongside SSRIs.
Active depression
Worsening depression
Coordinate care.
Discuss this combination with your prescriber. They may adjust timing, dosing, or switch to an alternative with fewer interaction risks. Never stop an antidepressant abruptly — taper under medical guidance.
Rifampin may reduce Celexa effectiveness.
Take Citalopram and Rifampin at their usual prescribed times. Some antibiotics (linezolid especially) have serotonergic properties and should never be combined with SSRIs — if you are on linezolid, confirm this combination with your prescriber. Standard antibiotics like amoxicillin or azithromycin are generally safe alongside SSRIs.
Worsening depression
Discuss this combination with your prescriber. They may adjust timing, dosing, or switch to an alternative with fewer interaction risks. Never stop an antidepressant abruptly — taper under medical guidance.
Coordinate care.
Or browse the full interaction database (121,000+ pairs).