MAJOR — Use With Caution
DANGEROUS — diazepam levels significantly reduced
Evidence level: STRONG
Rifampin makes Valium much less effective.
Rifampin induces CYP3A4 and CYP2C19. Diazepam is metabolized by both. Levels significantly reduced.
Consider switching to lorazepam or oxazepam during rifampin therapy (glucuronidated, not CYP-dependent).
Follow each medication's specific timing instructions. Rifampin — check if it requires an empty stomach or should be taken with food. Diazepam follows its normal schedule. Complete the full antibiotic course as prescribed.
Benzodiazepine dependence
Anxiety breakthrough, insomnia, withdrawal symptoms
Discuss alternative benzodiazepines not dependent on CYP metabolism.
Combining sedatives increases overdose risk. Discuss with your doctor: magnesium glycinate, L-theanine, or passionflower may provide anxiety relief with fewer interaction risks. Never stop benzodiazepines abruptly — taper under medical supervision.
Rifampin makes Valium much less effective.
Follow each medication's specific timing instructions. Rifampin — check if it requires an empty stomach or should be taken with food. Diazepam follows its normal schedule. Complete the full antibiotic course as prescribed.
Anxiety breakthrough, insomnia, withdrawal symptoms
Combining sedatives increases overdose risk. Discuss with your doctor: magnesium glycinate, L-theanine, or passionflower may provide anxiety relief with fewer interaction risks. Never stop benzodiazepines abruptly — taper under medical supervision.
Discuss alternative benzodiazepines not dependent on CYP metabolism.
Or browse the full interaction database (121,000+ pairs).