STOP — Contraindicated
FDA contraindication. Rifampin can reduce lurasidone exposure by approximately 80%. Lurasidone will be ineffective.
Evidence level: STRONG
Rifampin can make lurasidone (Latuda) completely ineffective by speeding up its breakdown in your body. The FDA says these should not be used together.
Rifampin is a strong CYP3A4 inducer. Can reduce lurasidone levels to subtherapeutic range. FDA lurasidone label contraindicates use with strong CYP3A4 inducers.
If you need rifampin, discuss alternative antipsychotic medications that are less affected by enzyme inducers.
Follow each medication's specific timing instructions. Rifampin — check if it requires an empty stomach or should be taken with food. Lurasidone follows its normal schedule. Complete the full antibiotic course as prescribed.
Higher risk for: those with liver or renal impairment, elderly, concurrent use of nephrotoxic or hepatotoxic drugs, history of C. difficile infection, or those on narrow therapeutic index medications (warfarin, digoxin).
Return of psychotic symptoms or mood instability due to subtherapeutic lurasidone levels
Discuss alternative antipsychotics less dependent on CYP3A4 during rifampin treatment.
Antibiotic interactions are often temporary (duration of treatment). Space supplements and probiotics 2-3 hours away from antibiotic doses. Ask your pharmacist if timing adjustments can reduce the interaction risk.
Rifampin can make lurasidone (Latuda) completely ineffective by speeding up its breakdown in your body. The FDA says these should not be used together.
Follow each medication's specific timing instructions. Rifampin — check if it requires an empty stomach or should be taken with food. Lurasidone follows its normal schedule. Complete the full antibiotic course as prescribed.
Return of psychotic symptoms or mood instability due to subtherapeutic lurasidone levels
Antibiotic interactions are often temporary (duration of treatment). Space supplements and probiotics 2-3 hours away from antibiotic doses. Ask your pharmacist if timing adjustments can reduce the interaction risk.
Discuss alternative antipsychotics less dependent on CYP3A4 during rifampin treatment.
Or browse the full interaction database (121,000+ pairs).