MAJOR — Use With Caution
DANGEROUS — reduced seizure/anxiety control
Evidence level: STRONG
Rifampin reduces Klonopin levels.
Rifampin induces CYP3A4. Clonazepam is a CYP3A4 substrate. Levels may be significantly reduced.
Monitor for breakthrough symptoms. Dose adjustment needed.
Follow each medication's specific timing instructions. Rifampin — check if it requires an empty stomach or should be taken with food. Clonazepam follows its normal schedule. Complete the full antibiotic course as prescribed.
Epilepsy, anxiety disorders, benzodiazepine dependence
Seizure breakthrough, anxiety, withdrawal symptoms
Coordinate between prescribers.
Combining sedatives increases overdose risk. Discuss with your doctor: magnesium glycinate, L-theanine, or passionflower may provide anxiety relief with fewer interaction risks. Never stop benzodiazepines abruptly — taper under medical supervision.
Rifampin reduces Klonopin levels.
Follow each medication's specific timing instructions. Rifampin — check if it requires an empty stomach or should be taken with food. Clonazepam follows its normal schedule. Complete the full antibiotic course as prescribed.
Seizure breakthrough, anxiety, withdrawal symptoms
Combining sedatives increases overdose risk. Discuss with your doctor: magnesium glycinate, L-theanine, or passionflower may provide anxiety relief with fewer interaction risks. Never stop benzodiazepines abruptly — taper under medical supervision.
Coordinate between prescribers.
Or browse the full interaction database (121,000+ pairs).