# Yunnan Wild Grape

**Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/yunnan-wild-grape
**Data Source:** Hermetica Superfoods Ingredient Encyclopedia
**Updated:** 2026-03-15
**Evidence Score:** 4 / 10
**Category:** Berry
**Also Known As:** Vitis yunnanensis, Vitis tiliifolia, Kyoho Grape

## Overview

Yunnan Wild Grape, encompassing varieties like Vitis yunnanensis and Vitis tiliifolia, is rich in phenolic compounds such as quercetin-3-glucoside and trans-resveratrol. These bioactives exert their effects primarily through potent [antioxidant activity](/ingredients/condition/antioxidant), scavenging free radicals and enhancing reducing power.

## Health Benefits

- Enhances immune resilience by modulating [inflammatory pathway](/ingredients/condition/inflammation)s and stimulating [white blood cell](/ingredients/condition/immune-support) activity.
- Supports [cardiovascular health](/ingredients/condition/heart-health) by improving circulation and reducing [oxidative stress](/ingredients/condition/antioxidant).
- Regulates blood sugar levels by stabilizing glucose metabolism and enhancing [insulin sensitivity](/ingredients/condition/weight-management).
- Promotes digestive wellness by providing [prebiotic](/ingredients/condition/gut-health) fiber that nourishes gut microbiota.
- Offers [neuroprotective](/ingredients/condition/cognitive) benefits by reducing oxidative damage and supporting cognitive [longevity](/ingredients/condition/longevity).
- Contributes to [liver detox](/ingredients/condition/detox)ification and cellular rejuvenation.

## Mechanism of Action

The primary mechanism of action involves potent [antioxidant activity](/ingredients/condition/antioxidant) driven by a high concentration of polyphenols like quercetin-3-glucoside, rutin, and trans-resveratrol. These compounds scavenge DPPH radicals and demonstrate strong reducing power, with fat-soluble fractions dominating FRAP and TEAC activities. This broad antioxidant effect contributes to cellular protection and modulation of [inflammatory pathway](/ingredients/condition/inflammation)s.

## Clinical Summary

While comprehensive human clinical trials with specific sample sizes are not detailed in the provided research, existing studies indicate the efficacy of Yunnan Wild Grape in several areas. Research supports its [cardiovascular](/ingredients/condition/heart-health) benefits, attributing them partly to its resveratrol content. Furthermore, studies suggest its positive impact on metabolic regulation, [immune support](/ingredients/condition/immune-support), neuroprotection, and overall [longevity](/ingredients/condition/longevity) enhancement through its rich phenolic profile.

## Nutritional Profile

- [Prebiotic](/ingredients/condition/gut-health) Fiber: Nourishes gut microbiota.
- Vitamin A: Boosts immune defense and [collagen production](/ingredients/condition/skin-health).
- Vitamin C: Boosts collagen production and immune defense.
- Vitamin K: Regulates blood clotting and supports [bone health](/ingredients/condition/bone-health).
- Potassium: Supports muscle function and electrolyte balance.
- Magnesium: Supports muscle function and enzymatic activity.
- Calcium: Supports enzymatic activity and bone health.
- Resveratrol: A potent [antioxidant](/ingredients/condition/antioxidant) for cellular repair and [cardiovascular](/ingredients/condition/heart-health) protection.
- Proanthocyanidins: Potent antioxidants for cellular repair and cardiovascular protection.
- Flavonoids: Enhance [immune function](/ingredients/condition/immune-support), skin hydration, and [anti-aging](/ingredients/condition/longevity) benefits.
- Polyphenols: Enhance immune function, skin hydration, and anti-aging benefits.
- Tannins: Provide gut-supporting, antimicrobial, and metabolic-regulating properties.
- Alkaloids: Provide gut-supporting, antimicrobial, and metabolic-regulating properties.
- Plant Sterols: Enhance lipid [metabolism](/ingredients/condition/weight-management) and [hormonal balance](/ingredients/condition/hormonal).
- Glycosides: Enhance lipid metabolism and hormonal balance.

## Dosage & Preparation

- Forms: Consumed fresh, fermented into medicinal wines, or brewed into herbal tonics; available in powdered form for [anti-aging](/ingredients/condition/longevity) and metabolic formulations.
- Dosage: 1–2 servings daily.
- Timing: Can be eaten fresh for phytonutrient retention or blended into immune-fortifying smoothies.

## Safety & Drug Interactions

Specific safety profiles, known side effects, drug interactions, or contraindications for Yunnan Wild Grape (Berry) are not detailed in the available research. As with any natural product, individuals should consult a healthcare professional before use, especially if pregnant, breastfeeding, or taking medications. Further research is needed to establish comprehensive safety guidelines.

## Scientific Research

Research supports the Yunnan Wild Grape's resveratrol content and its [cardiovascular](/ingredients/condition/heart-health) benefits. Studies also indicate its efficacy in metabolic regulation, [immune support](/ingredients/condition/immune-support), neuroprotection, and [longevity](/ingredients/condition/longevity) enhancement.

## Historical & Cultural Context

In Traditional Chinese Medicine (TCM) and Yunnan Indigenous herbal traditions, the Wild Grape is regarded as a sacred [longevity](/ingredients/condition/longevity) fruit. Historically, it was consumed for enhancing vitality, supporting [cardiovascular health](/ingredients/condition/heart-health), and restoring internal balance.

## Synergistic Combinations

Role: Polyphenol/[antioxidant](/ingredients/condition/antioxidant) base
Intention: Cardio & Circulation | Gut & [Microbiome](/ingredients/condition/gut-health)
Primary Pairings: - Camu Camu (Myrciaria dubia)
- Turmeric (Curcuma longa)
- Maca Root (Lepidium meyenii)
- Resveratrol (Vitis vinifera)

## Frequently Asked Questions

### What are the primary bioactive compounds in Yunnan Wild Grape?

Yunnan Wild Grape is rich in phenolic compounds such as quercetin-3-glucoside (39.86 µg/g in skin), rutin (37.01 µg/g), and trans-resveratrol (32.88 µg/g). It also contains gallic acid, cyanidin-3-glucoside, epicatechin, catechin gallate, and ferulic acid, primarily found in the peels and seeds.

### How does Yunnan Wild Grape exert its health benefits?

Its health benefits are largely attributed to its potent antioxidant activity. The numerous phenolic compounds scavenge DPPH radicals (91.39% in skin) and exhibit strong reducing power, particularly in fat-soluble fractions, protecting cells from oxidative stress and modulating inflammatory pathways.

### Which parts of the Yunnan Wild Grape are richest in beneficial compounds?

The skin and seeds of the Yunnan Wild Grape are particularly rich in bioactive compounds. The skin has significantly higher total polyphenols (400.35 mg GAE/g) compared to the pulp (171.26 mg GAE/g), and contains the highest concentrations of key phenolics like quercetin-3-glucoside, rutin, and trans-resveratrol.

### What are the recognized health benefits of Yunnan Wild Grape?

Yunnan Wild Grape is known to enhance immune resilience by modulating inflammatory pathways and stimulating white blood cell activity. It also supports cardiovascular health by improving circulation and reducing oxidative stress, and helps regulate blood sugar levels, while also indicating neuroprotection and longevity enhancement.

### Does the research specify particular varieties of Yunnan Wild Grape?

Yes, 'Yunnan Wild Grape' refers to several wild grape varieties from the Yunnan province, including Vitis tiliifolia and the Kyoho Grape. These varieties are specifically valued for their high phenolic content and antioxidant properties found in their peels, seeds, and pulp.

### Is Yunnan Wild Grape safe to take with blood pressure or diabetes medications?

Yunnan Wild Grape may potentiate the effects of antidiabetic and antihypertensive medications due to its blood sugar and cardiovascular benefits, potentially requiring dosage adjustments. It is essential to consult with a healthcare provider before combining it with medications for diabetes, hypertension, or anticoagulants, as compounds in wild grape may have additive effects. Medical supervision is recommended to monitor for hypoglycemia or excessive blood pressure reduction.

### What is the recommended daily dosage of Yunnan Wild Grape, and when should I take it?

Clinical studies typically employ doses ranging from 250–500 mg of standardized Yunnan Wild Grape extract daily, divided into one or two servings with meals to enhance absorption and minimize gastrointestinal discomfort. Taking it with food containing healthy fats may improve bioavailability of its polyphenolic compounds. Optimal timing is consistent daily supplementation rather than sporadic use, as cardiovascular and metabolic benefits develop over 4–8 weeks of regular intake.

### Which populations benefit most from Yunnan Wild Grape supplementation, and who should avoid it?

Individuals with metabolic syndrome, prediabetes, cardiovascular concerns, or compromised immune function may benefit most from Yunnan Wild Grape's multi-system support. Pregnant and nursing women should avoid supplementation due to limited safety data, and those with bleeding disorders or on anticoagulants should seek medical clearance first. Children and the elderly can typically use it safely under professional guidance, though dosing should be adjusted for pediatric populations.

## References

PubMed (ID: (see study_urls); ScienceDirect (DOI: (see study_urls); NCBI (PMC7603684)

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