Hermetica Superfood Encyclopedia
Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.
Review flags: AWAITING_SEMANTIC_VALIDATION
Lactobacillus fermentum ME-3 is a clinically studied probiotic strain that produces glutathione and antimicrobial compounds to support gut health and immune function. This strain enhances antioxidant defenses by increasing intracellular glutathione levels while modulating intestinal microbiota composition.
Reported Benefits (Provisional)
Origin & History
Lactobacillus fermentum ME-3 is a strain of probiotic bacteria isolated from the human gastrointestinal tract. It is produced through a fermentation process involving controlled cultivation in nutrient-rich media. This strain is known for its antioxidative properties.
Research Narrative (Provisional)
Numerous clinical trials, including randomized controlled trials, have demonstrated its antioxidative and gut health benefits. Meta-analyses affirm its role in enhancing immune function.
Preparation & Dosage
Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.
Nutritional Profile
- Contains high levels of glutathione, a powerful antioxidant. - Produces lactic acid, which aids in gut health. - Rich in enzymes that support digestion.
Reported Mechanism (Provisional)
Lactobacillus fermentum ME-3 produces glutathione synthetase and glutathione reductase enzymes, increasing intracellular glutathione concentrations by up to 49%. The strain synthesizes antimicrobial peptides and short-chain fatty acids that inhibit pathogenic bacteria while strengthening tight junction proteins in the intestinal barrier. It modulates immune responses through interaction with Toll-like receptors and production of anti-inflammatory cytokines like IL-10.
Clinical Narrative (Provisional)
Human studies with 20-40 participants show Lactobacillus fermentum ME-3 supplementation (2-6 billion CFU daily) increases blood glutathione levels by 30-49% within 3 weeks. Clinical trials demonstrate reduced oxidative stress markers, improved lipid profiles with 7-15% cholesterol reduction, and enhanced immune responses. However, most studies are small-scale and short-term, requiring larger randomized controlled trials for definitive therapeutic claims. Evidence is strongest for antioxidant and gut health benefits.
Also Known As
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