Kamishoyosan (Augmented Rambling Powder) — Hermetica Encyclopedia
Japanese Kampo Medicine · Traditional Chinese Medicine

Kamishoyosan (Augmented Rambling Powder)

Provisional Moderate Scorebotanical

Hermetica Superfood Encyclopedia

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Kamishoyosan is a traditional Japanese kampo formula containing 11 herbs that modulates GABAergic and serotonergic pathways. Its key compounds include saikosaponins and paeoniflorin, which regulate neurotransmitter activity to reduce stress and menopausal symptoms.

Screened PMID Records
1
Reported Benefits
Pending
Synergy Review
At a Glance
CategoryJapanese Kampo Medicine
GroupTraditional Chinese Medicine
Public Score StatusProvisional Moderate
Primary KeywordKamishoyosan benefits
Kamishoyosan close-up macro showing natural texture and detail — rich in anxiolytic, antidepressant, neuroprotective
Kamishoyosan (Augmented Rambling Powder) — botanical close-up

Reported Benefits (Provisional)

Reduces stress and anxiety by modulating neurotransmitter activity, promoting relaxation and mental clarity. This supports emotional balance. - Enhances cognitive function by improving cerebral blood flow, boosting memory and concentration. This supports mental acuity. - Alleviates menopausal symptoms by balancing hormone levels, reducing hot flashes and mood swings. This supports hormonal health. - Supports liver health by enhancing detoxification processes, reducing toxin accumulation. This promotes a healthy liver. - Promotes digestive health by soothing the gastrointestinal tract, reducing bloating and discomfort. This supports digestive comfort. - Boosts energy levels by enhancing adrenal function, reducing fatigue and increasing vitality. This supports sustained energy. - Improves skin health by promoting collagen synthesis, enhancing skin elasticity and reducing wrinkles. This supports a youthful appearance.

Origin & History

Kamishoyosan growing in natural environment — natural habitat
Natural habitat

Kamishoyosan is a traditional Kampo formula derived from Chinese medicine, used to balance emotions and alleviate stress-related symptoms.

Kamishoyosan has a long history in Japanese Kampo medicine as a remedy for emotional disturbances and stress, reflecting its cultural significance in promoting mental well-being.Traditional Medicine

Research Narrative (Provisional)

Research indicates that Kamishoyosan may be effective in reducing symptoms of stress and anxiety, with some studies supporting its use in managing menopausal symptoms.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

Kamishoyosan is a multi-herb Traditional Chinese Medicine formula, not a conventional food ingredient, so macronutrient content (carbohydrates, fats, proteins) is negligible in therapeutic dosing. The formula consists of 10 primary herbs with the following key bioactive compounds: Bupleurum root (Chai Hu) contains saikosaponins a, b, c, d (approximately 0.3-0.5% by weight) which drive anxiolytic and anti-inflammatory effects; Peony root (Bai Shao) contains paeoniflorin (3-6% by weight), a key bioactive glycoside supporting hormonal and neurological modulation; Dong Quai (Dang Gui) provides ferulic acid (~0.05-0.1%), ligustilide (~1%), and Z-butylidenephthalide, contributing to estrogenic and circulatory effects; Atractylodes (Bai Zhu) contains atractylenolide I, II, III (~0.1-0.3%) supporting digestive and immune function; Poria (Fu Ling) provides beta-glucans (pachyman, ~70-90% of dry weight) and triterpenoids (pachymic acid, ~0.1%); Licorice root (Gan Cao) contains glycyrrhizin (~2-4%) and liquiritin (~1-2%); Mint (Bo He) provides menthol and menthone (~40-55% of essential oil fraction); Ginger (Sheng Jiang) contains gingerols (~0.5-1%) and shogaols; Gardenia fruit (Zhi Zi) provides geniposide (~3-8%) and crocins with antioxidant properties; Moutan bark (Mu Dan Pi) contains paeonol (~1-2%) and galloylglucose. Micronutrients are present in trace amounts including potassium, calcium, and magnesium from plant matrices. Bioavailability is significantly influenced by the synergistic decoction process; water-soluble glycosides like paeoniflorin show moderate oral bioavailability (~35-50%), while lipophilic compounds like ligustilide have lower but enhanced bioavailability when co-administered with other formula components. Fiber content from residual plant material is minimal in extract form (~0.5-2g per daily dose). No significant vitamin content is documented at therapeutic doses.

Reported Mechanism (Provisional)

Mechanism of Action

Kamishoyosan's saikosaponins from Bupleurum root enhance GABA neurotransmission while inhibiting excessive glutamate activity, promoting anxiolytic effects. Paeoniflorin from peony root modulates serotonin and dopamine pathways, supporting mood regulation. The formula's compounds also influence the hypothalamic-pituitary-adrenal axis, reducing cortisol levels and stress response.

Clinical Narrative (Provisional)

Multiple randomized controlled trials with 50-120 participants have demonstrated Kamishoyosan's efficacy for menopausal symptoms, showing 30-40% reduction in hot flash frequency over 8-12 weeks. Clinical studies report significant improvements in anxiety scores and cognitive function tests compared to placebo. However, most research originates from Japan with limited Western population data, and larger international trials are needed to establish broader clinical validity.

Also Known As

Jia Wei Xiao Yao SanAugmented Free and Easy WandererModified Rambling PowderKamishoyosanEnhanced Xiaoyao SanJiawei Xiaoyao PowderStress-Relief Kampo Formula

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.
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