MAJOR — Use With Caution
DANGEROUS — additive respiratory depression
Evidence level: STRONG
Combining amitriptyline with oxycodone causes dangerous sedation and breathing suppression.
Additive CNS and respiratory depression from TCA + opioid.
Minimize doses if combination necessary. Avoid concurrent alcohol.
Take Oxycodone exactly as prescribed — set alarms for scheduled doses. Amitriptyline follows its normal schedule. Opioids slow GI transit, which can affect absorption of other medications. Take with food if nausea occurs. Never combine with alcohol.
Elderly, respiratory disease, sleep apnea
Extreme sedation, respiratory depression, confusion
Discuss risk vs benefit of this combination.
Opioid combinations carry serious risks including respiratory depression. Talk to your pain management specialist about non-opioid alternatives: physical therapy, NSAIDs (if appropriate), nerve blocks, or non-sedating supplements like PEA (palmitoylethanolamide) or curcumin for inflammation.
Combining amitriptyline with oxycodone causes dangerous sedation and breathing suppression.
Take Oxycodone exactly as prescribed — set alarms for scheduled doses. Amitriptyline follows its normal schedule. Opioids slow GI transit, which can affect absorption of other medications. Take with food if nausea occurs. Never combine with alcohol.
Extreme sedation, respiratory depression, confusion
Opioid combinations carry serious risks including respiratory depression. Talk to your pain management specialist about non-opioid alternatives: physical therapy, NSAIDs (if appropriate), nerve blocks, or non-sedating supplements like PEA (palmitoylethanolamide) or curcumin for inflammation.
Discuss risk vs benefit of this combination.
Or browse the full interaction database (121,000+ pairs).