STOP — Contraindicated
⛔ CONTRAINDICATED — NEVER combine alcohol with Oxycodone.
Evidence level: STRONG
Alcohol with oxycodone is potentially fatal. Alcohol can also cause extended-release oxycodone to release its entire dose at once.
Combined CNS and respiratory depression. Alcohol increases oxycodone absorption from extended-release formulations (dose dumping).
Never drink alcohol while taking oxycodone. Extended-release forms are especially dangerous as alcohol causes sudden release of the full dose.
Taking Oxycodone with food can reduce nausea, a common side effect. Alcohol — high-fiber foods can help combat opioid-induced constipation. Avoid grapefruit juice with some opioids (oxycodone, fentanyl) as it can increase blood levels. Never combine opioids with alcohol.
Extended-release formulations, any alcohol amount, elderly
Extreme drowsiness, blue lips, slow/stopped breathing, unable to wake
Keep naloxone available. Discuss complete alcohol abstinence.
Opioid combinations carry serious risks including respiratory depression. Talk to your pain management specialist about non-opioid alternatives: physical therapy, NSAIDs (if appropriate), nerve blocks, or non-sedating supplements like PEA (palmitoylethanolamide) or curcumin for inflammation.
Alcohol with oxycodone is potentially fatal. Alcohol can also cause extended-release oxycodone to release its entire dose at once.
Taking Oxycodone with food can reduce nausea, a common side effect. Alcohol — high-fiber foods can help combat opioid-induced constipation. Avoid grapefruit juice with some opioids (oxycodone, fentanyl) as it can increase blood levels. Never combine opioids with alcohol.
Extreme drowsiness, blue lips, slow/stopped breathing, unable to wake
Opioid combinations carry serious risks including respiratory depression. Talk to your pain management specialist about non-opioid alternatives: physical therapy, NSAIDs (if appropriate), nerve blocks, or non-sedating supplements like PEA (palmitoylethanolamide) or curcumin for inflammation.
Keep naloxone available. Discuss complete alcohol abstinence.
Or browse the full interaction database (121,000+ pairs).