MAJOR — Use With Caution
DANGEROUS — blocks opioid effects; causes withdrawal
Evidence level: STRONG
Naltrexone completely blocks oxycodone. Can trigger severe withdrawal in dependent patients.
Naltrexone blocks mu-opioid receptors, eliminating oxycodone effects. Precipitates withdrawal in dependent patients.
Must be opioid-free 7-10 days before naltrexone.
Take Oxycodone exactly as prescribed — set alarms for scheduled doses. Naltrexone follows its normal schedule. Opioids slow GI transit, which can affect absorption of other medications. Take with food if nausea occurs. Never combine with alcohol.
Opioid dependence, recent opioid use
Precipitated withdrawal, loss of pain relief
Carry medical ID card. Ensure adequate washout period.
Opioid combinations carry serious risks including respiratory depression. Talk to your pain management specialist about non-opioid alternatives: physical therapy, NSAIDs (if appropriate), nerve blocks, or non-sedating supplements like PEA (palmitoylethanolamide) or curcumin for inflammation.
Naltrexone completely blocks oxycodone. Can trigger severe withdrawal in dependent patients.
Take Oxycodone exactly as prescribed — set alarms for scheduled doses. Naltrexone follows its normal schedule. Opioids slow GI transit, which can affect absorption of other medications. Take with food if nausea occurs. Never combine with alcohol.
Precipitated withdrawal, loss of pain relief
Opioid combinations carry serious risks including respiratory depression. Talk to your pain management specialist about non-opioid alternatives: physical therapy, NSAIDs (if appropriate), nerve blocks, or non-sedating supplements like PEA (palmitoylethanolamide) or curcumin for inflammation.
Carry medical ID card. Ensure adequate washout period.
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