STOP — Contraindicated
FDA Black Box Warning — avoid concurrent use. Use lowest doses and shortest duration if absolutely necessary.
Evidence level: STRONG
Taking oxycodone with diazepam is extremely dangerous. Both slow your breathing and can cause fatal respiratory depression. The FDA requires its strongest warning label on this combination.
Combined CNS depression: opioid mu-receptor agonism plus GABA-A receptor potentiation. FDA Black Box Warning on both drug classes.
Do not combine these medications without direct medical supervision. Avoid alcohol entirely. Have someone check on you if both are prescribed.
Take Diazepam only as prescribed — benzodiazepines carry dependence risk and should not be adjusted without medical guidance. Oxycodone at a separate time. Benzodiazepines cause sedation — avoid combining with other sedating substances. Never increase dose without medical guidance.
Risk increases with higher doses of either substance, older age, liver or kidney impairment, and concurrent use of other serotonergic or CNS-depressant substances.
Extreme drowsiness, slow or stopped breathing, confusion, bluish skin color, inability to wake up
Discuss alternatives: Can a non-opioid manage your pain? Can a non-benzodiazepine manage your anxiety or muscle spasms?
Opioid combinations carry serious risks including respiratory depression. Talk to your pain management specialist about non-opioid alternatives: physical therapy, NSAIDs (if appropriate), nerve blocks, or non-sedating supplements like PEA (palmitoylethanolamide) or curcumin for inflammation.
Taking oxycodone with diazepam is extremely dangerous. Both slow your breathing and can cause fatal respiratory depression. The FDA requires its strongest warning label on this combination.
Take Diazepam only as prescribed — benzodiazepines carry dependence risk and should not be adjusted without medical guidance. Oxycodone at a separate time. Benzodiazepines cause sedation — avoid combining with other sedating substances. Never increase dose without medical guidance.
Extreme drowsiness, slow or stopped breathing, confusion, bluish skin color, inability to wake up
Opioid combinations carry serious risks including respiratory depression. Talk to your pain management specialist about non-opioid alternatives: physical therapy, NSAIDs (if appropriate), nerve blocks, or non-sedating supplements like PEA (palmitoylethanolamide) or curcumin for inflammation.
Discuss alternatives: Can a non-opioid manage your pain? Can a non-benzodiazepine manage your anxiety or muscle spasms?
Or browse the full interaction database (121,000+ pairs).